Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Touradj EbrahimiTouradj EBRAHIMI received his M.Sc. and Ph.D., both in Electrical Engineering, from the Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland, in 1989 and 1992 respectively. In 1993, he was a research engineer at the Corporate Research Laboratories of Sony Corporation in Tokyo, where he conducted research on advanced video compression techniques for storage applications. In 1994, he served as a research consultant at AT&T Bell Laboratories working on very low bitrate video coding. He is currently Professor at EPFL heading its Multimedia Signal Processing Group. He is also the Convenor of JPEG standardization Committee. He was also adjunct Professor with the Center of Quantifiable Quality of Service at Norwegian University of Science and Technology (NTNU)from 2008 to 2012.
Prof. Ebrahimi has been the recipient of various distinctions and awards, such as the IEEE and Swiss national ASE award, the SNF-PROFILE grant for advanced researchers, Four ISO-Certificates for key contributions to MPEG-4 and JPEG 2000, and the best paper award of IEEE Trans. on Consumer Electronics . He became a Fellow of the international society for optical engineering (SPIE) in 2003. Prof. Ebrahimi has initiated more than two dozen National, European and International cooperation projects with leading companies and research institutes around the world. He is a co-founder of Genista SA, a high-tech start-up company in the field of multimedia quality metrics. In 2002, he founded Emitall SA, start-up active in the area of media security and surveillance. In 2005, he founded EMITALL Surveillance SA, a start-up active in the field of privacy and protection. He is or has been associate Editor with various IEEE, SPIE, and EURASIP journals, such as IEEE Signal Processing Magazine, IEEE Trans. on Image Processing, IEEE Trans. on Multimedia, EURASIP Image Communication Journal, EURASIP Journal of Applied Signal Processing, SPIE Optical Engineering Magazine. Prof. Ebrahimi is a member of Scientific Advisory Board of various start-up and established companies in the general field of Information Technology. He has served as Scientific Expert and Evaluator for Research Funding Agencies such as those of European Commission, The Greek Ministry of Development, The Austrian National Foundation for Scientific Research, The Portuguese Science Foundation, as well as a number of Venture Capital Companies active in the field of Information Technologies and Communication Systems. His research interests include still, moving, and 3D image processing and coding, visual information security (rights protection, watermarking, authentication, data integrity, steganography), new media, and human computer interfaces (smart vision, brain computer interface).
He is the author or the co-author of more than 200 research publications, and holds 14 patents. Prof. Ebrahimi is a member of IEEE, SPIE, ACM and IS&T.
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http://mmspl.epfl.ch Emma Elizabeth TolleyI studied the universe at the smallest scales at the Large Hadron Collider, now we're getting ready to study it at the largest scales with the Square Kilometer Array. My research focuses on developing high-performance computing and new data science techniques to image and analyse the radio sky.
Teaching & PhD PhD Students Markus Johan Bredberg, Ashutosh Kumar Mishra Past EPFL PhD Students as codirector Shreyam Parth Krishna Courses General physics : mechanics (english flipped classroom) PHYS-101
Iva Tkalcec VâjuTeaching & PhD Past EPFL PhD Students as codirector Lucas Degeneve Courses Physics lab (metrology) PHYS-117 This course is a practical introduction to classical measurement techniques in a physics laboratory. It aims at familiarising the students with data acquisition, sensors, signal processing, vacuum and cryogenics. Physics lab IIIa PHYS-319 The students observe a number of physical phenomena and their technological applications. The course aims at acquiring knowledge abou
Olga FinkTeaching & PhD PhD Students Han Sun, Leandro Von Krannichfeldt, Keivan Faghih Niresi, Zepeng Zhang, Vinay Sharma, Chenghao Xu, Raffael Pascal Theiler, Kevin Antonio Steiner, Sergei Garmaev, Amaury Wei Past EPFL PhD Students Ismail Nejjar, Mengjie Zhao Courses Data Science for infrastructure condition monitoring CIVIL-332 The course will cover the relevant steps of data-driven infrastructure condition monitoring, starting from data acquisition, going through the steps pre-processing of real
Giovanna AmbrosiniCurrent Position Senior Scientist, School of Life Sciences, Bioinformatics Competence Center, école Polythechnique Fédérale de Lausanne, Lausanne.Senior bioinformatician and software engineer with proven experience working in higher education institutions. Solid experience in scientific computing and web design. Proficient in physics and computational genomics, with a focus on high-throughput genomic sequencing data analysis (ChIP-seq, ATAC-seq, RNA-seq, scRNA-seq, and exome sequencing) and other types of
Olivier SchneiderAfter his thesis defense in particle physics in 1989 at University of Lausanne, Olivier Schneider joins LBL, the Lawrence Berkeley Laboratory (California), to work on the CDF experiment at the Tevatron in Fermilab (Illinois), first as a research fellow supported by the Swiss National Science Foundation, and later as a post-doc at LBL. He participates in the construction and commissioning of the first silicon vertex detector to operate successfully at a hadron collider; this detector enabled the discovery of the sixth quark, named "top". Since 1994, he comes back to Europe and participates in the ALEPH experiment at CERN's Large Electron-Positron Collider, as CERN fellow and then as CERN scientific staff. He specializes in heavy flavour physics. In 1998, he becomes associate professor at University of Lausanne, then extraordinary professor at the Swiss Institute of Technology Lausanne (EPFL) in 2003, and finally full professor at EPFL in 2010. Having worked since 1997 on the preparation of the LHCb experiment at CERN's Large Hadron Collider, which started operation in 2009, he is now analyzing the first data. He also contributes since 2001 to the exploitation of the data recorded at the Belle experiment (KEK laboratory, Tsukuba, Japan). These two experiments study mainly the decays of hadrons containing a b quark, as well CP violation, i.e. the non-invariance under the symmetry between matter and antimatter.
Jean-Louis ScartezziniDirector of EPFL Solar Energy and Building Physics Laboratory (1994-present); Founder & Director of ENAC Institute of Infrastructures, Resources and Environment (2002-2009); Founder & Director of EPFL Doctoral Program in Environment (2002-2009); Co-Director of EPFL Institute of Building Technology (1994-1997); Associate Professor of Building Physics at EPFL (1994-1997); Associate Professor of Building Physics at University of Geneva (1990-1997); Group Leader & Research Fellow at the EPFL Solar Energy Research Group (1981-1989); Research Fellow at the Applied Geophysics Institute of University of Lausanne (1980-1981).
Raphaël DefertTeaching & PhD Courses Risk analysis and management CIVIL-438 The course aims to train students in methods and tools allowing them to understand the issue of analysis and management of technological and natural risks in a well-founded and scientific manner, with attention paid to the field of Civil Engineering.
Rolf GruetterAwards:
1999 Young Investigator Award Plenary Lectureship
, International Society for Neurochemistry
2011 Fellow
, ESMRMB
2011 Teaching Award
, Section Sciences de la Vie, EPFL
Quentin GalleaTeaching & PhD Courses Data Science & Causal Inference for Sustainability MGT-499 This class explores key climate questions through data. Students will learn to collect, clean, and analyze data, apply causal methods using Python, and communicate insights clearly. With a focus on sustainability, the course builds skills to avoid pitfalls and draw meaningful conclusions. Economics for challenging times MGT-494 This course analyzes socio-economic issues related to poverty, inequ
