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Concept

Peptidoglycan

Related publications (29)

Cell-wall deficient L. monocytogenes L-forms feature abrogated pathogenicity

Nicola Harris

Stable L-forms are cell wall-deficient bacteria which are able to multiply and propagate indefinitely, despite the absence of a rigid peptidoglycan cell wall. We investigated whether L-forms of the intracellular pathogen L. monocytogenes possibly retain pa ...

Frontiers Research Foundation2014

Listeria phage A511, a model for the contractile tail machineries of SPO1-related bacteriophages

Petr Leiman, Mikhail Shneyder

Recognition of the bacterial host and attachment to its surface are two critical steps in phage infection. Here we report the identification of Gp108 as the host receptor-binding protein of the broad host-range, virulent Listeria phage A511. The ligands fo ...

Wiley-Blackwell2014

Targeting Bacterial Central Metabolism for Drug Development

John McKinney, Paul Murima

Current antibiotics, derived mainly from natural sources, inhibit a narrow spectrum of cellular processes, namely DNA replication, protein synthesis, and cell wall biosynthesis. With the worldwide explosion of drug resistance, there is renewed interest in ...

Elsevier2014

New evidence for TiO2 uniform surfaces leading to complete bacterial reduction in the dark: Critical issues

César Pulgarin, Juan Kiwi, Sami Rtimi, Danièle Laub

This study presents new evidence for the events leading to Escherichia coil reduction in the absence of light irradiation on TiO2-polyester (from now on TiO2-PES. By transmission electron microscopy (TEM) the diffusion of TiO2 NP's aggregates with the E. c ...

Elsevier Science Bv2014

Deleterious effect of homogeneous and heterogeneous near-neutral photo-Fenton system on Escherichia coli. Comparison with photo-catalytic action of TiO2 during cell envelope disruption

César Pulgarin, Andrzej Sienkiewicz, Cristina del Socorro Lonfat

The mechanisms underlying bacterial inactivation by solar photo-Fenton at near-neutral pH have not yet been investigated in detail. In particular, no consensus exists on the bacterial inactivation mechanism under solar light enhanced by the Fenton's reagen ...

Elsevier Science Bv2014

Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases

Stewart Cole, Benoit Lechartier

We report the discovery of a series of new drug leads that have potent activity against Mycobacterium tuberculosis as well as against other bacteria, fungi, and a malaria parasite. The compounds are analogues of the new tuberculosis (TB) drug SQ109 (1), wh ...

Amer Chemical Soc2014

Functional Analysis of PGRP-LA in Drosophila Immunity

Bruno Lemaitre, Juan Camilo Paredes Escobar

PeptidoGlycan Recognition Proteins (PGRPs) are key regulators of the insect innate antibacterial response. Even if they have been intensively studied, some of them have yet unknown functions. Here, we present a functional analysis of PGRP-LA, an as yet unc ...

Public Library of Science2013

The Phosphate Specific Transport (Pst) System in Fast- and Slow-Growing Mycobacteria

Cyntia De Piano

Although mycobacteria are known to accumulate polyphosphate (PolyP), a linear polymer of orthophosphate, when subjected to stresses, the exact roles of this molecule are not yet clearly understood. We found that deletion of the pstA gene encoding for a tra ...

EPFL2013

Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE

Bruno Lemaitre, Claudine Danielle Patricia Öngen

The Drosophila antimicrobial response is one of the best characterized systems of pattern recognition receptor-mediated defense in metazoans. Drosophila senses Gram-negative bacteria via two peptidoglycan recognition proteins (PGRPs), membrane-bound PGRP-L ...

American Association of Immunologists ; Oxford University Press2012