Publications related to Proton-pump inhibitor

De novo designed proteins: a study in engineering novel folds and functions

Proteins control nearly every facet of life on a molecular level. Proteins are formed from linear strings of amino acids, which fold into three-dimensional structures that can enact functions. Evolution has created highly efficient proteins in diverse fold ...

EPFL2023

Rational design of protein switches: applications in synthetic biology and cancer immunotherapy

Sailan Shui

Synthetic biology aims to engineer cells as miniature biological devices to sense, process, and respond to exogenous stimuli. Protein switches are designed to sense and respond to various molecular queues in a fast and specific manner, which fits the requi ...

EPFL2022

Computational design of novel protein–protein interactions – An overview on methodological approaches and applications

Bruno Emanuel Ferreira De Sousa Correia, Anthony Marchand, Alexandra Krina Van Hall-Beauvais

Protein–protein interactions (PPIs) govern numerous cellular functions in terms of signaling, transport, defense and many others. Designing novel PPIs poses a fundamental challenge to our understanding of molecular interactions. The capability to robustly ...

2022

Inhibition of Thiol‐Mediated Uptake with Irreversible Covalent Inhibitors

Jérôme Waser, Eliott Hugo Joran Le Du, Elija Grinhagena, Abhaya Kumar Mishra

Thiol-mediated uptake is emerging as method of choice to penetrate cells. This study focuses on irreversible covalent inhibitors of thiol-mediated uptake. High-content high-throughput screening of the so far largest collection of hypervalent iodine reagent ...

Wiley-VHCA AG2021

Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery

Yimon Aye, Bokyoung Kim

Protein-protein interactions (PPIs) are an effective means to orchestrate intricate biological processes required to sustain life. Approximately 650000 PPIs underlie the human interactome; thus underscoring its complexity and the manifold signaling outputs ...

WILEY-V C H VERLAG GMBH2019

Intricacies of Cation-Anion Combinations in Imidazolium Salt-Catalyzed Cycloaddition of CO2 Into Epoxides

Paul Joseph Dyson, Gabor Laurenczy, Felix Daniel Bobbink, Martin Hulla, Dmitry Vasilyev, Florent Menoud

The cycloaddition of CO2 into epoxides catalyzed by imidazolium and related salts continues to attract attention due to the industrial importance of the cyclic carbonate products. The mechanism of the imidazolium-catalyzed transformation has been proposed ...

2018

Dual-pump generation of high-coherence primary Kerr combs with multiple sub-lines

Tobias Kippenberg, Maxim Karpov, Martin Hubert Peter Pfeiffer, Arne Kordts, Yan Yan

We experimentally generate high-coherence primary Kerr combs with multiple sub-lines by using dual pumps and demonstrate the application of a primary comb state in multichannel communications. We find that more than 10 primary comb lines can be generated w ...

Optical Society of America2017

Experimental Generation of High-Coherence Sub-Prime Comb Lines with Multiple Sub-Lines in a Kerr Frequency Comb using Dual Pumps

Tobias Kippenberg, Maxim Karpov, Martin Hubert Peter Pfeiffer, Arne Kordts, Yan Yan

The generation of primary sub-comb-lines with high coherence using dual pumps in a SiN microresonator is investigated. A total capacity of 400 Gbit/s has been experimentally demonstrated in coherent communications based on the generated combs. ...

Ieee2016

Lansoprazole is an antituberculous prodrug targeting cytochrome bc1

Stewart Cole, Claudia Sala, Florence Pojer, Andrej Benjak, Anthony Vocat, Philippe Busso, Jan Lars Rybniker

Better antibiotics capable of killing multi-drug-resistant Mycobacterium tuberculosis are urgently needed. Despite extensive drug discovery efforts, only a few promising candidates are on the horizon and alternative screening protocols are required. Here, ...

Nature Publishing Group2015

Hydrogen Evolution at Liquid–Liquid Interfaces

Hubert Girault, Xile Hu, Heron Vrubel, Bin Su, Imren Hatay

Blowing bubbles: Hydrogen evolution by proton reduction with [(C5Me5)2Fe] occurs at a soft interface between water and 1,2-dichloroethane (DCE). The reaction proceeds by proton transfer assisted by [(C5Me5)2Fe] across the water–DCE interface with subsequen ...

Wiley-VCH Verlag GmbH2009

Proton Pump for O2 Reduction Catalyzed by 5,10,15,20- Tetraphenylporphyrinatocobalt(II)

Hubert Girault, Bin Su

The role of 5,10,15,20-tetraphenylporphyrinatocobalt(II) ([Co-(tpp)]) as a catalyst on molecular oxygen (O2) reduction by ferrocene (Fc) and its two derivatives, 1,1’-di-methylferrocene (DFc) and decamethylferrocene (DMFc) at a polarized water¦1,2-dichloro ...

2009