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Concept

Focal adhesion

Related publications (26)

Investigating Focal Adhesion Substructures by Localization Microscopy

Aleksandra Radenovic, Daniel Sage, Hendrik Georges Deschout, Lely Feletti

Cells rely on focal adhesions (FAs) to carry out a variety of important tasks, including motion, environmental sensing, and adhesion to the extracellular matrix. Although attaining a fundamental characterization of FAs is a compelling goal, their extensive ...

Elsevier2017

Combining PALM and SOFI for quantitative imaging of focal adhesions in living cells

Theo Lasser, Aleksandra Radenovic, Tomas Lukes, Hendrik Georges Deschout, Lely Feletti, Azat Sharipov

Focal adhesions are complicated assemblies of hundreds of proteins that allow cells to sense their extracellular matrix and adhere to it. Although most focal adhesion proteins have been identified, their spatial organization in living cells remains challen ...

Spie-Int Soc Optical Engineering2017

Complementarity of PALM and SOFI for super-resolution live-cell imaging of focal adhesions

Theo Lasser, Aleksandra Radenovic, Marcel Leutenegger, Daniel Pawel Szlag, Tomas Lukes, Hendrik Georges Deschout, Lely Feletti, Azat Sharipov

Live-cell imaging of focal adhesions requires a sufficiently high temporal resolution, which remains a challenge for super-resolution microscopy. Here we address this important issue by combining photoactivated localization microscopy (PALM) with super-res ...

Nature Publishing Group2016

Proteolytic processing of the synaptic cell adhesion molecule neurexin-3beta and the neurobiological functions of the resulting cleavage products

Magda Maria Palczynska

Neurexins are key synaptic cell adhesion molecules involved in synapse specification and maturation. They couple synaptic activity and cell adhesion to regulate activity-dependent synapse development. Recently, neurexin processing by alpha- and gamma- secr ...

EPFL2016

Fibroblast adhesion on ECM-derived peptide modified poly(2-hydroxyethyl methacrylate) brushes: Ligand co-presentation and 3D-localization

Harm-Anton Klok, Solenne Desseaux

Polymer brushes prepared via surface-initiated polymerization of 2-hydroxyethyl methacrylate are powerful platforms for the fabrication of model biointerfaces to study cell-substrate interactions. In this manuscript, the versatility of surface-initiated po ...

Elsevier2015

Mechanical properties of peripheral stress fibers in adherent cells spreading on patterned substrates

Céline Jeanne Labouesse

Many cellular processes require or depend on mechanical feedback from the cell's micro-environment. For example, the local organization of the actin cytoskeleton is known to adapt to the physical properties of the extracellular matrix. To gain better under ...

EPFL2015