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Related publications (27)

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Elucidating regulatory mechanisms shaping the transcriptome and proteome of the gut immune response in Drosophila melanogaster

Michael Vincent Frochaux

Work on Drosophila melanogaster paved the way to our current understanding of modern genetics. Since then, this model organism has contributed greatly to various fields such as neurobiology, development, and immunology. The discovery and analysis of the va ...

EPFL2019

The effect of frontoparietal paired associative stimulation on decision-making and working memory

Traian Popa

Previous single-site neurostimulation experiments have unsuccessfully attempted to shift decision-making away from habitual control, a fast, inflexible cognitive strategy, towards goal-directed control, a flexible, though computationally expensive strategy ...

2019

Predicting the Occurrence of Variants in RAG1 and RAG2

Jacques Fellay, Flavia Aurelia Shoko Hodel, Dylan Lawless

While widespread genome sequencing ushers in a new era of preventive medicine, the tools for predictive genomics are still lacking. Time and resource limitations mean that human diseases remain uncharacterized because of an inability to predict clinically ...

2019

Visual masking and schizophrenia: enhancement deficit 200 ms after stimulus onset

Michael Herzog, Maya Roinishvili, Ophélie Gladys Favrod, Janir Nuno Ramos Antunes Da Cruz

Masking is strongly deteriorated in schizophrenia patients and to a lesser extent in their healthy relatives. For this reason, masking is a good endophenotype. Here, we show the EEG correlates of masking across the schizophrenia continuum in order to tackl ...

2018

Efficient inference for genetic association studies with multiple outcomes

Anthony Christopher Davison, Jörg Hager, Hélène Ruffieux

Combined inference for heterogeneous high-dimensional data is critical in modern biology, where clinical and various kinds of molecular data may be available from a single study. Classical genetic association studies regress a single clinical outcome on ma ...

Oxford University Press2017

Inferring the age and strength of mutations evolving under positive selection

Nicky Louise Ormond

A fundamental goal of population genetics is to determine and quantify the interplay of mutation, natural selection, genetic drift and migration in shaping allelic frequency changes that underpin evolution-ary change. In this dissertation, I present comput ...

EPFL2017

SQC: Secure Quality Control for Meta-Analysis of Genome-Wide Association Studies

Jean-Pierre Hubaux, Jacques Fellay, Zhicong Huang, Huang Lin

Motivation: Due to the limited power of small-scale genome-wide association studies (GWAS), researchers tend to collaborate and establish a larger consortium in order to perform large-scale GWAS. Genome-wide association meta-analysis (GWAMA) is a statistic ...

Oxford University Press2017