Laurent VillardTeaching & PhD Past EPFL PhD Students Matteo Maccio, Olivier Fischer, Gloria Luisa Falchetto, Paolo Angelino, Sébastien Jolliet, Xavier Lapillonne, Thibaut Vernay, Julien Stanislas Pierre Dominski, Gabriele Merlo, Emmanuel Lanti, Noé Ohana, Moahan Murugappan
Stefano CodaTeaching & PhD PhD Students Vincent Masson, Luigi Persico, Ewout Koen L. Devlaminck, Martino Bonisolli, Alessandro Balestri, Mackenzie Peter-Fulford Van Rossem, James Winston Irawati Tumbokon, Salomon Guinchard, Inès Vergara, Michele Bottino Past EPFL PhD Students Alessandro Marinoni, Silvano Gnesin, Cornelis Adrianus de Meijere, Josef Kamleitner, Zhouji Huang, Himank Anand, Pedro Andres Molina Cabrera, Dahye Choi, Federico Pesamosca, Aylwin Iantchenko, Jean Arthur Cazabonne
Paul Joseph DysonPaul Dyson joined the Institute of Chemical Sciences and Engineering at the EPFL in 2002 where he heads the Laboratory of Organometallic and Medicinal Chemistry and between 2008 and 2016 chaired the Institute. He has won several prizes including the Werner Prize of the Swiss Chemical Society in 2004, the Award for Outstanding Achievements in Bioorganometallic Chemistry in 2010, the Centennial Luigi Sacconi Medal of the Italian Chemical Society in 2011, the Bioinorganic Chemistry Award of the Royal Society of Chemistry in 2015, the European Sustainable Chemistry Award of the European Chemical Society in 2018 and the Green Chemistry Award from the Royal Society of Chemistry in 2020. He is also a Clarivate Highly Cited Researcher and has an H-index >110 (web of science and google scholar). He was elected a Fellow of the Royal Society of Chemistry in 2010, a Fellow of the European Academy of Science in 2019 and a life-long fellow of the American Association for the Advancement of Science in 2020. Over the years he has held visiting professorships at the University of Bourgogne, University of Pierre et Marie Curie, University of Vienna, University of Rome Tor Vergara, Chimie Paristech and Shangai Jiao Tong University.Since 2016 he has been Member of the Council of the Division of Mathematics, Natural and Engineering Sciences at the Swiss National Science Foundation.Between 2016-2021 he has been Member of the Council of the Division of Mathematics, Natural and Engineering Sciences at the Swiss National Science Foundation. In 2021 he was appointed Dean of the Faculty of Basic Sciences.
Shaik Mohammed ZakeeruddinTeaching & PhD Past EPFL PhD Students as codirector Magdalena Anna Marszalek, Jiyoun Seo, Marko Stojanovic, Natalie Flores Diaz, Anwar Qasem M Alanazi, Thomas Paul Baumeler, Essa Awadh R Alharbi, Masaud Hassan S Almalki
Karin Lederballe MeibomEducation PhD | Molecular Biology 1997 – 1997 University of Southern Denmark (Odense University), Denmark Directed by Advisor: Poul Valentin-Hansen Professionals experiences Postdoctoral researcher 2000–2004 Stanford University, USAPostdoctoral researcher 2005–2007 INSERM, Paris, FranceChargee de recherche 2007–2012 INSERM, Paris, FranceScientist Laboratory of Experimental Biophysics 2013–2014 EPFL
Teaching & PhD Past EPFL PhD Students as codirector Solenne Anne
Rizlan Bernier-LatmaniHIGHER EDUCATION
Summer course: Advances in Genome Technology and Bioinformatics Course at the Marine Biology Laboratory in Woods Hole, MA. October 2005.
Ph.D. 2001 Civil and Environmental Engineering, Stanford University, CA
(Advisor, Jim Leckie, Biodegradation of uranyl (UO22 )-complexed citrate and implications for uranyl mobility in the subsurface)
M.S. 1995 Civil and Environmental Engineering, Stanford University, CA
B.S. 1993 Natural Resources with Honors, Cornell University, Ithaca, NY
PROFESSIONAL EMPLOYMENT
2013-present Associate professor with tenure, School of Architecture, Civil and Environmental Engineering, Swiss Federal Institute of Technology, Lausanne
2005-2013 Assistant professor tenure track, School of Architecture, Civil and Environmental Engineering, Swiss Federal Institute of Technology, Lausanne
2001-2005 Post-Graduate Researcher, Scripps Institution of Oceanography, La Jolla, CA (PI: Brad Tebo)
1995-2001 Graduate Research Assistant, Stanford University (Advisor: Jim Leckie)
RESEARCH INTERESTS
Gemicrobiology, metal-bacteria interactions, biological reduction and oxidation of metals, biological nanoparticle formation; Characterization of microbial communities in terrestrial environments; Using genomic, microscopic and spectroscopic tools to understand metal transformations by microorganisms.
ACADEMIC HONORS
Rotary Foundation University Professor grant, 2004.
Swiss National Science Foundation Post-doctoral Fellowship, 2001.
Leon B. Reynolds Memorial Scholarship in the School of Engineering at Stanford University, 1995-96.
Graduated with Honors from Cornell University, 1993.
BIBLIOMETRY
http://www.researcherid.com/rid/E-4398-2011
ResearcherID: E-4398-2011 Camille Véronique Bernadette GoemansCamille's research focuses on understanding how antibiotics and non-antibiotic drugs affect the diverse bacteria from the human gut microbiota and how they contribute to dysbiosis and the development of antibiotic resistance. To achieve this goal, she combines systems approaches with molecular microbiology, bacterial genetics and biochemistry.She obtained her Bachelor's and Master's degrees in Biomedical Sciences from the UCLouvain, Belgium, after which she completed her PhD (FRIA national fellowship) at th
Hubert GiraultEducation: 1979 - Engineering diploma from Grenoble Institute of Technology. FRANCE. 1982 - PhD- Department of Chemistry, University of Southampton. Thesis entitled : Interfacial studies using drop image processing techniques. Positions : 1982 - 1984 SERC Research Fellow. University of Southampton. 1984 - 1985 CNRS Research Fellow. University of Southampton. 1985 - 1992 Lecturer in Physical Chemistry, University of Edinburgh. 1992 - Professor of Physical Chemistry, Ecole Polytechnique Fédérale de Lausanne. 2011 - 2014 Dean of Bachelor and Master studies Hubert Girault is the author of 2 textbooks, the co-author of about 600 scientific publications with more than 20'000 citations and the co-inventor of more than 15 patents. During his academic career, he has supervised 70 PhD students. 30 alumni of his laboratory are now Professors. Honours: Faraday medal 2006, Royal Society of Chemistry, Fellow of the International Society of Electrochemistry 2007, Reilley Award 2015. Fellow of the Electrochemical Society (USA), Shikata International medal, Polarography Society of Japan. Associate editor of Chemical Science
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Olivier SauterTeaching & PhD PhD Students Cassandre Ekta Contré, Antonia Frank, Peizheng Zhang, Jean-Pierre Thomas Svantner, Cristina Venturini, Cosmas Quirin Lorenz Heiss, Daniel Perales Rios, Viacheslav Bochkarev, Jan Jakub Frybes, Paul Véronique Guillaume Devianne Past EPFL PhD Students Clemente Angioni, Petri Nikkola, Alberto Bottino, Andrei Martynov, Emiliano Fable, Costanza Zucca, Federico Felici, Dávid Wágner, Doohyun Kim, Anna Teplukhina, Mengdi Kong, Francesco Carpanese, Simon Van Mulders, Stefano Marchioni, F
Bernard SchneiderTeaching & PhD PhD Students Yesica Gloria, Christian Schellhaas Past EPFL PhD Students Vanessa Laversenne, Sameer Mohammad Khaleel Nazeeruddin, Emma Charlotta Källstig Past EPFL PhD Students as codirector Philippe Guillaume Coune, Emilda Pino, Elisabeth Anne Dirren, Aurélien Lathuilière, Wojciech Janusz Bobela, Lu Zheng, Cylia Cloé Rochat Courses Methods: from disease models to therapy BIOENG-518 This course will describe methods underlying translational approaches from disease modeling an
