Concept

Staphylococcus

Related publications (26)

Bactericidal activity and mechanism of action of copper-sputtered flexible surfaces against multidrug-resistant pathogens

César Pulgarin, Juan Kiwi, Sami Rtimi, Myriam Koumba Sarah Ballo

Using direct current magnetron sputtering (DCMS), we generated flexible copper polyester surfaces (Cu-PES) and investigated their antimicrobial activity against a range of multidrug-resistant (MDR) pathogens including eight Gram-positive isolates (three me ...

Springer Verlag2016

Development of potent and selective S. aureus sortase A inhibitors Based on Peptide Macrocycles

Christian Heinis, Inmaculada Rentero Rebollo, Davide Bertoldo

Sortases are transpeptidase enzymes that anchor surface proteins, including virulence factors, to the cell wall of Gram-positive bacteria, and they are potential targets for the development of anti-infective agents. While several large compound libraries w ...

2016

In Vitro and In Vivo Effectiveness of an Innovative Silver-Copper Nanoparticle Coating of Catheters To Prevent Methicillin-Resistant Staphylococcus aureus Infection

César Pulgarin, Juan Kiwi, Sami Rtimi, Myriam Koumba Sarah Ballo

In this study, silver/copper (Ag/Cu)-coated catheters were investigated for their efficacy in preventing methicillin-resistant Staphylococcus aureus (MRSA) infection in vitro and in vivo. Ag and Cu were sputtered (67/33% atomic ratio) on polyurethane cathe ...

American Society for Microbiology2016

Sensitive and fast identification of bacteria in blood samples by immunoaffinity mass spectrometry for quick BSI diagnosis

Hubert Girault, Horst Pick, Liang Qiao, Natalia Gasilova, Alexandra Bondarenko, Niels Erik Lion, Michel Prudent, Yingdi Zhu

Bloodstream infections rank among the most serious causes of morbidity and mortality in hospitalized patients, partly due to the long period (up to one week) required for clinical diagnosis. In this work, we have developed a sensitive method to quickly and ...

Royal Soc Chemistry2016

Surface Grafted Polymer Brushes : A Versatile Platform for Antibacterial Applications

Sorin Alexandru Ibanescu

Various strategies have been proposed and applied to prepare antibacterial materials able to respond to different requirements specific for antibacterial applications. Among diverse strategies the approach based on substrates modification with polymer brus ...

EPFL2015

Improving Bicyclic Peptide Phage Display and Development of Sortase A Inhibitors

Inmaculada Rentero Rebollo

Bicyclic peptide ligands are promising molecules for the development of new therapeutics. They combine advantages from large protein therapeutics and small molecule drugs. Large combinatorial libraries of bicyclic peptides can be generated and screened by ...

EPFL2014