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Concept

G beta-gamma complex

Related publications (24)

Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway

Horst Arthur Vogel, Shuguang Yuan

Recent crystal structures of G-protein-coupled receptors (GPCRs) have revealed ordered internal water molecules, raising questions about the functional role of those waters for receptor activation that could not be answered by the static structures. Here, ...

Nature Publishing Group2014

Assembly of the Transmembrane Domain of E. coli PhoQ Histidine Kinase: Implications for Signal Transduction from Molecular Simulations

Matteo Dal Peraro, Thomas Lemmin

The PhoQP two-component system is a signaling complex essential for bacterial virulence and cationic antimicrobial peptide resistance. PhoQ is the histidine kinase chemoreceptor of this tandem machine and assembles in a homodimer conformation spanning the ...

Public Library Science2013

MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington's Disease-Related Mechanisms

Ana Jovicic

Background: Whereas many causes and mechanisms of neurodegenerative diseases have been identified, very few therapeutic strategies have emerged in parallel. One possible explanation is that successful treatment strategy may require simultaneous targeting o ...

Public Library Science2013

Downscaling the Analysis of Complex Transmembrane Signaling Cascades to Closed Attoliter Volumes

Horst Arthur Vogel, Rudolf Hovius, Romain Wyss, Joachim Piguet, Luigino Grasso, Ghérici Hassaïne, Michael Werner

Cellular signaling is classically investigated by measuring optical or electrical properties of single or populations of living cells. Here we show that ligand binding to cell surface receptors and subsequent activation of signaling cascades can be monitor ...

Public Library of Science2013