Bruno Emanuel Ferreira De Sousa CorreiaThroughout my PhD and postdoctoral studies I was trained in world-renowned laboratories and institutions in the United States of America (University of Washington and The Scripps Research Institute). Very early in my scientific career I found out my fascination about protein structure and function. My PhD studies evolved in the direction of immunogen design and vaccine engineering which sparked my interest in the many needs and opportunities in vaccinology and translational research. My efforts resulted in an enlightening piece of work where for the first time, computationally designed immunogens elicited potent neutralizing antibodies. During my postdoctoral studies I joined a chemical biology laboratory at the Scripps Research Institute. In this stage I developed novel chemoproteomics methods for the identification of protein-small molecule interaction sites in complex proteomes. In March 2015, I joined the École Polytechnique Fédérale de Lausanne (EPFL) – Switzerland as a tenure track assistant professor. The focus of my research group is to develop computational tools for protein design with particular emphasis in applying these strategies to immunoengineering (e.g. vaccine and cancer immunotherapy). The activities in my laboratory focus on computational design methods development and experimental characterization of the designed proteins. Our laboratory has been awarded with 2 prestigious research grants from the European Research Council. Lastly, I have been awarded the prize for best teacher of Life sciences in 2019.
Ambrogio FasoliAmbrogio FASOLI was born on November 10, 1964, in Milano, Italy. After a classical high school diploma (Maturità Classica) and graduation from the University of Milano, with the degree of Dottore in Fisica, he obtained his Phd at the Ecole Polytechnique Fédérale (EPFL) with a thesis on chaos in wave-particle interactions in plasmas, which was awarded the Best EPFL Thesis prize, in 1993. He then moved to the JET Joint Undertaking, the largest worlds fusion device, near Oxford, UK, to investigate Alfvén waves and burning plasma physics. In 1995-1996 he took a sabbatical leave, visiting several Universities and Research Institutes in Europe and in the USA, including three months at General Atomics in San Diego. In 1996-1997, during a second period at JET, he participated in the fusion power worlds record experiments in Deuterium-Tritium plasmas at JET. In 1997 he was nominated Assistant Professor in MIT Physics Department, where he led a basic plasma physics group and the international collaboration between MIT and JET. In 2001 Ambrogio FASOLI was nominated Assistant Professor of Physics at EPFL, Lausanne, Switzerland, and Professeur Boursier of the Swiss National Science Foundation. He became member of CRPP Directorate and took the leadership of CRPP basic plasma physics group and of the TCV tokamak, one of the major fusion experiments worldwide. At European level he was scientific coordinator for JET experiments, spokesperson for multi-machine experiments in the frame of International Tokamak Physics Activities, and Project Leader for a JET Enhancement project. In 2005 he became Associate Professor of Physics with tenure at EPFL, then member of EFDA Science and Technology Advisory Committee, and of the Steering Committee of the Association EURATOM-Swiss Confederation. From 2006 he was also Deputy Director, then from 2007 Executive Director of CRPP and from 2008 Full Professor of Physics at EPFL. For a number of years he was the Chair of the EPFL Physics Strategic Committee and a member of the Directorate of the EPFL School of Sciences. Since the summer of 2014 Professor FASOLI was the sole Director of CRPP. He now represents Switzerland in the EUROfusion General Assembly and Bureau, and in the Governing Board for Fusion for Energy. He is member of the EUROfusion DEMO project Board, of the Scientific Board of the Helmotz Virtual Institute on Advanced Microwave Diagnostics, of the European Delegation for the Cooperation between Euratom and the Government of India in Fusion Energy Research, of the European Consortium for the development of the ITER gyratron (EGYC), and participates to numerous international review panels. He chairs the FuseNet Academic Council, the International Advisory Panel for the Laboratory of Excellence Plas@Par in the Sorbonne Universities, the European Consortium for the construction of the ITER microwave Upper Launcher (ECHUL), and the Promotion Committee of the EPFL Faculty of Basic Sciences. He is one the three European representatives in the International Tokamak Physics Activities Coordinating Committee, advising ITER, and the Editor-in-Chief of the IAEA journal Nuclear Fusion. Since January 2019, Ambrogio Fasoli is the Chair of the General Assembly, i.e. the president of EUROfusion, the European Consortium for Development of Fusion Energy. Professor FASOLI is a Fellow of the American Physical Society and since 2001 a Visiting Professor at MIT Physics Department. He is the Director of the Swiss Plasma Center.
Yves MartinTeaching & PhD Past EPFL PhD Students as codirector Francesco Piras, Jonathan Rossel Courses Fusion and industrial plasma technologies PHYS-632 The course provides an overview of the technologies that are essential for fusion developments and for industrial plasmaapplications, highlighting the synergies between the two fields. The aim is to provide a combined theoretical andexperimental background to the various topics.
Olivier SauterTeaching & PhD PhD Students Cassandre Ekta Contré, Antonia Frank, Peizheng Zhang, Jean-Pierre Thomas Svantner, Cristina Venturini, Cosmas Quirin Lorenz Heiss, Daniel Perales Rios, Viacheslav Bochkarev, Jan Jakub Frybes, Paul Véronique Guillaume Devianne Past EPFL PhD Students Clemente Angioni, Petri Nikkola, Alberto Bottino, Andrei Martynov, Emiliano Fable, Costanza Zucca, Federico Felici, Dávid Wágner, Doohyun Kim, Anna Teplukhina, Mengdi Kong, Francesco Carpanese, Simon Van Mulders, Stefano Marchioni, F
Stefano CodaTeaching & PhD PhD Students Vincent Masson, Luigi Persico, Ewout Koen L. Devlaminck, Martino Bonisolli, Alessandro Balestri, Mackenzie Peter-Fulford Van Rossem, James Winston Irawati Tumbokon, Salomon Guinchard, Inès Vergara, Michele Bottino Past EPFL PhD Students Alessandro Marinoni, Silvano Gnesin, Cornelis Adrianus de Meijere, Josef Kamleitner, Zhouji Huang, Himank Anand, Pedro Andres Molina Cabrera, Dahye Choi, Federico Pesamosca, Aylwin Iantchenko, Jean Arthur Cazabonne
Duccio TestaProfessionals experiences Supply teacher of mathematics, physics and computing 1994–1995 various high schools in Torino (Italy)
Teaching & PhD Past EPFL PhD Students as codirector Theodoros Panis, Lorenzo Stipani Courses Sustainable energy innovation HUM-292 This course provides an introduction to the technical, social, and economic fundamentals of energy. The course examines the concrete case of nuclear fusion. How could this energy reshape our world? How can we ensure its acceptability, st
Vassily HatzimanikatisDr. Vassily Hatzimanikatis is currently Associate Professor of Chemical Engineering and Bioengineering at Ecole Polytechnique Federale de Lausanne (EPFL), in Lausanne, Switzerland. Vassily received a PhD and an MS in Chemical Engineering from the California Institute of Technology, and his Diploma in Chemical Engineering from the University of Patras, in Greece. After the completion of his doctoral studies, he held a research group leader position at the Swiss Federal Institute of Technology in Zurich (ETHZ), Switzerland. Prior to joining EPFL, Vassily worked for three years in DuPont, Cargill, and Cargill Dow, and he has been assistant professor at Northwestern University, at Illinois, USA.
Vassilys research interests are in the areas of computational systems biology, biotechnology, and complexity. He is associate editor of the journals Biotechnology & Bioengineering, Metabolic Engineering and Integrative Biology, and he serves on the editorial advisory board of the journals Bioprocess and Biosystems Engineering, Journal of Chemical Technology and Biotechnology, and Industrial Biotechnology. He has written over 70 technical publications and he is co-inventor in three patents and patent applications.
Vassily is a fellow of the American Institute for Medical and Biological Engineering (2010), he was a DuPont Young Professor (2001-2004), and he has also received the Jay Bailey Young Investigator Award in Metabolic Engineering (2000), and the ACS Elmar Gaden Award (2011).
Guido HaefeliTeaching & PhD PhD Students Federico Ronchetti, Gauri Napoletano Past EPFL PhD Students as codirector Axel Kuonen, Olivier Göran Girard, Carina Trippl Courses Particle detection PHYS-440 The course will cover the physics of particle detectors. It will introduce the experimental techniques used in nuclear and particle physics. The lecture includes the interaction of particles with matter, scintillators, gas detectors, silicon detectors, detectors for particle ID and photo-detectors.
Olivier SchneiderAfter his thesis defense in particle physics in 1989 at University of Lausanne, Olivier Schneider joins LBL, the Lawrence Berkeley Laboratory (California), to work on the CDF experiment at the Tevatron in Fermilab (Illinois), first as a research fellow supported by the Swiss National Science Foundation, and later as a post-doc at LBL. He participates in the construction and commissioning of the first silicon vertex detector to operate successfully at a hadron collider; this detector enabled the discovery of the sixth quark, named "top". Since 1994, he comes back to Europe and participates in the ALEPH experiment at CERN's Large Electron-Positron Collider, as CERN fellow and then as CERN scientific staff. He specializes in heavy flavour physics. In 1998, he becomes associate professor at University of Lausanne, then extraordinary professor at the Swiss Institute of Technology Lausanne (EPFL) in 2003, and finally full professor at EPFL in 2010. Having worked since 1997 on the preparation of the LHCb experiment at CERN's Large Hadron Collider, which started operation in 2009, he is now analyzing the first data. He also contributes since 2001 to the exploitation of the data recorded at the Belle experiment (KEK laboratory, Tsukuba, Japan). These two experiments study mainly the decays of hadrons containing a b quark, as well CP violation, i.e. the non-invariance under the symmetry between matter and antimatter.
Paola ViganòTeaching & PhD PhD Students Noélie Marion Charlotte Lecoanet, Shyam Sunder Sirimalla Past EPFL PhD Students Roberto Sega, Antoine Vialle, Tommaso Pietropolli, Sylvie Tram Nguyen, Anna Karla De Almeida Milani, Elena Calafati, Flore Jeanne Marie Andrea Guichot Courses Hidden rivers PENS-219 Hidden Rivers aims at fulfilling the need for an interdisciplinary understanding of the problematics surrounding urban streams, through ecological, hydrological, and spatial relationships found in riversc
Jean-Paul Richard KneibExpertise
Cosmology, Gravitational Lensing, Redshift Survey, First Galaxies, Cluster of Galaxies, Fiber-positioner robotic system, Radio Astronomy, Space Sustainibility
Current work
- Former Principal investigator of the SDSS-IV eBOSS project. This is an international project assembling more than 150 participants located mainly in Europe, USA and China. This project will observe 1.5 million galaxy and quasars over 2014-2020 to accurately measure the expansion history of the Universe. * Member of the DESI co
Dominique PiolettiDominique Pioletti received his Master in Physics from the Swiss Federal Institute of Technology Lausanne (EPFL) in 1992. He pursued his education in the same Institution and obtained his PhD in biomechanics in 1997. He developed original constitutive laws taking into account viscoelasticity in large deformations. Then he spent two years at UCSD as post-doc fellow acquiring know-how in cell and molecular biology. He was interested in particular to gene expression of bone cells in contact to orthopedic implant. In April 2006, Dominique Pioletti was appointed Assistant Professor tenure-track at the EPFL and is director of the Laboratory of Biomechanical Orthopedics. His research topics include biomechanics and tissue engineering of musculo-skeletal tissues; mechano-transduction in bone; development of orthopedic implant as drug delivery system. Since 2013, he has been promoted to the rank of Associate Professor.
Emre TelatarI. Emre Telatar received the B.Sc. degree in electrical engineering from the Middle East Technical University, Ankara, Turkey, in 1986. He received the S.M. and Ph.D. degrees in electrical engineering and computer science from the Massachusetts Institute of Technology, Cambridge, in 1988 and 1992 respectively. In 1992, he joined the Communications Analysis Research Department at AT&T Bell Laboratories (later Lucent Technologies), Murray Hill, NJ. He has been at the EPFL since 2000.
Emre Telatar was the recipient of the IEEE Information Theory Society Paper Award in 2001. He was a program co-chair for the IEEE International Symposium on Information Theory in 2002, and associate editor for Shannon Theory for the IEEE Information Theory Transactions from 2001 to 2004. He was awarded the EPFL Agepoly teaching prize in 2005.
Emre Telatar's research interests are in communication and information theories.
Michaël UnserExpertise
Image Processing, Medical Imaging, Biological Imaging, Wavelets, Splines, Multiresolution
Michael Unser is Full Professor with EPFL’s school of Engineering and the academic director of EPFL's Center for Imaging, Lausanne, Switzerland. His primary areas of investigation are signal processing, biomedical imaging and applied functional analysis. He is internationally recognized for his research contributions to sampling theory, wavelets, the use of splines for image processing, stochastic processes,
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Jonathan GravesProf. Jonathan P. Graves is a Senior Scientist at EPFL and Honorary Visiting Professor at the University of York, UK. He achieved first class joint honours in Electronic Engineering and Mathematics from the University of Nottingham, UK in 1996. He completed his Ph.D. in Theoretical Mechanics from the University of Nottingham, UK, three years later in 1999. During his Ph.D. he was based in the Culham theory group of the United Kingdom Atomic Energy Authority, developing kinetic descriptions of the internal kink instability, and participating in deuterium-tritium experimental analysis in the Joint European Torus. After a short time in industry, and a postdoc at Nottingham University, he took a position at the Swiss Plasma Center at EPFL, becoming a Senior Scientist in 2014, and became an Honorary Visiting Professor at the University of York, UK, in 2020. In 2015 he became a member of the EUROfusion Scientific and Technical Advisory Committee (STAC) and a member of the EUROfusion DEMO Technical Advisory Group. He is on the editorial board for the journal Plasma Physics and Controlled Fusion, and in 2020 became Scientific Secretary of the Varenna-Lausanne International Workshop in Theory of Fusion Plasmas.
Aude BillardExpertise
RoboticsMachine LearningArtificial IntelligenceHuman-Robot InteractionMechatronicsDynamical Systems ControlComputational Neuroscience
Aude Billard is full professor and head of the LASA laboratory at the School of Engineering at the Swiss Institute of Technology Lausanne (EPFL), and the Director of the Swiss Innovation Booster on Robotics. Dr. Billard acts as the President of the IEEE Robotics and Automation Society (RAS), after serving in several roles in the administrative and executive committe
Serge VaudenaySerge Vaudenay entered at the Ecole Normale Supérieure in 1989 with a major in mathematics. He earned his agrégation (secondary teaching degree) in mathematics in 1992, then a PhD in Computer Science at the University of Paris 7 - Denis Diderot in 1995. He subsequently became a senior research fellow at the CNRS, prior to being granted his habilitation à diriger des recherches (a postdoctoral degree authorizing the recipient to supervise doctoral students). In 1999, he was appointed as a Professor at the EPFL, where he created the Security and Cryptography Laboratory.
