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Concept

Ventricular remodeling

Related publications (31)

Nuclear receptor corepressor 1 represses cardiac hypertrophy

Johan Auwerx, Chao Li, Jun Wang, Yan Liu

The function of nuclear receptor corepressor 1 (NCoR1) in cardiomyocytes is unclear, and its physiological and pathological implications are unknown. Here, we found that cardiomyocyte-specific NCoR1 knockout (CMNKO) mice manifested cardiac hypertrophy at b ...

2019

Sequential Bone-Marrow Cell Delivery of VEGFA/S1P Improves Vascularization and Limits Adverse Cardiac Remodeling After Myocardial Infarction in Mice

Michele De Palma, Mario Leonardo Squadrito

Microvascular dysfunction and resulting tissue hypoxia is a major contributor to the pathogenesis and evolution of cardiovascular diseases (CVD). Diverse gene and cell therapies have been proposed to preserve the microvasculature or boost angiogenesis in C ...

MARY ANN LIEBERT, INC2019

In vivo pulse labeling of isochronic cohorts of cells in the central nervous system using FlashTag

Subashika Govindan

The tracing of neuronal cell lineages is critical to our understanding of cellular diversity in the CNS. This protocol describes a fluorescence birth-dating technique to label, track and isolate isochronic cohorts of newborn cells in the CNS in vivo in mou ...

NATURE PUBLISHING GROUP2018

A transmurally heterogeneous orthotropic activation model for ventricular contraction and its numerical validation

Alfio Quarteroni, Luca Dede', Simone Rossi, Luca Barbarotta

Models for cardiac mechanics require an activation mechanism properly representing the stress-strain relations in the contracting myocardium. In this paper, we propose a new activation model that accounts for the transmural heterogeneities observed in myoc ...

Wiley2018

Estimating Left Ventricular Elastance from Aortic Flow Waveform, Ventricular Ejection Fraction, and Brachial Pressure: An In Silico Study

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou

Although left ventricular end-systolic elastance (E-es) serves as a major index of cardiac contractility, a widely-accepted noninvasive estimation of E-es does not exist. To overcome this limitation, we developed a two-step inverse method that allows for i ...

SPRINGER2018

Numerical approximation of cardiac electro-fluid-mechanical models : coupling strategies for large-scale simulation

Antonello Gerbi

The mathematical modeling of the heart involves several challenges, which are intrinsically related to the complexity of its function. A satisfactory cardiac model must be able to describe a wide range of different processes, such as the evolution of the t ...

EPFL2018

The LifeV library: engineering mathematics beyond the proof of concept

Simone Deparis, Luca Formaggia, Davide Forti

LifeV is a library for the finite element (FE) solution of partial differential equations in one, two, and three dimensions. It is written in C++ and designed to run on diverse parallel architectures, including cloud and high performance computing faciliti ...

2018

Total arterial compliance, estimated by a novel method, is better related to left ventricular mass compared to aortic pulse wave velocity: The SAFAR study

Nikolaos Stergiopoulos

Aim: The investigation of the association between total arterial compliance (C-T)-estimated by a novel technique-with left ventricular mass (LVM) and hypertrophy (LVH). Our hypothesis was that C-T may be better related to LVM compared to the gold-standard ...

Taylor & Francis Inc2017

A matrix DEIM technique for model reduction of nonlinear parametrized problems in cardiac mechanics

Alfio Quarteroni, Andrea Manzoni

When relying on Newton iterations to solve nonlinear problems in the context of Reduced Basis (RB) methods, the assembling of the RB arrays during the online stage depends on the dimension of the underlying high-fidelity approximation. This is more of an i ...

Elsevier Science Sa2017

Social isolation stress and chronic glutathione deficiency have a common effect on the glutamine-to-glutamate ratio and myo-inositol concentration in the mouse frontal cortex

João Miguel das Neves Duarte, Rolf Gruetter, Alberto Corcoba

Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative effects ...

Wiley-Blackwell2017

Non-invasive hemodynamic monitoring by electrical impedance tomography

Martin Proença

The monitoring of central hemodynamic parameters such as cardiac output (CO) and pulmonary artery pressure (PAP) is of paramount clinical importance to assess the health status of the cardiovascular system. However, their measurement requires the insertion ...

EPFL2017