Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Denis GilletDenis Gillet received the Diploma in Electrical Engineering from the Swiss Federal Institute of Technology in Lausanne (EPFL) in 1988, and the Ph.D. degree in Information Systems also from the EPFL in 1995. During 1992 he was appointed as Research Fellow at the Information Systems Laboratory of Stanford University in the United States. He is currently Maître d'enseignement et de recherche at the EPFL School of Engineering, where he leads the React research group. His current research interests include Technologies Enhanced Learning (TEL), Human Computer Interaction (HCI), Human Devices Interaction (HDI) and Optimal Coordination of Complex and Distributed Systems. Denis Gillet is affiliated at EPFL with the Center for Intelligent Systems and the Center for Digital Education.
Pierre DillenbourgA former teacher in elementary school, Pierre Dillenbourg graduated in educational science (University of Mons, Belgium). He started his research on learning technologies in 1984. In 1986, he has been on of the first in the world to apply machine learning to develop a self-improving teaching system. He obtained a PhD in computer science from the University of Lancaster (UK), in the domain of artificial intelligence applications for education. He has been assistant professor at the University of Geneva. He joined EPFL in 2002. He has been the director of Center for Research and Support on Learning and its Technologies, then academic director of Center for Digital Education, which implements the MOOC strategy of EPFL (over 2 million registrations). He is full professor in learning technologies in the School of Computer & Communication Sciences, where he is the head of the CHILI Lab: "Computer-Human Interaction for Learning & Instruction ». He is the director of the leading house DUAL-T, which develops technologies for dual vocational education systems (carpenters, florists,...). With EPFL colleagues, he launched in 2017 the Swiss EdTech Collider, an incubator with 80 start-ups in learning technologies. He (co-)-founded 4 start-ups, does consulting missions in the corporate world and joined the board of several companies or institutions. In 2018, he co-founded LEARN, the EPFL Center of Learning Sciences that brings together the local initiatives in educational innovation. He is a fellow of the International Society for Learning Sciences. He currently is the Associate Vice-President for Education at EPFL.
Jean-Marc OdobezExpertise
Computer Vision, machine Learning (Bayesian models, deep learning), multimodal processing.Activity analysis, human behavior understanding, human communication, interaction modeling
Dr Jean-Marc Odobez (Msc 1990, PhD 1994) received his Ph.D degree from Rennes University in 1994 for his PhD dissertation done at INRIA. After 5 years as an assistant professor at the University du Maine, France, he decided to join Idiap, where he is now the Head of the Perception & Activity Understanding Group and adju
Daniel BurnierExpertise
Altium Designer CADDigital ElectronicsTechnical support
Mission
Electronic SupportAltium Designer support
Claudia Rebeca Binder SignerClaudia R. Binder, a Swiss, Canadian and Colombian citizen, was born in Montreal and spent most of her childhood in Switzerland and Colombia. She studied at ETH Zurich from 1985 to 1996, earning a degree in biochemistry and then a PhD in environmental sciences. After conducting her post-doctoral research at the University of Maryland in the US from 1996 to 1998, she returned to Switzerland and took a position as a senior research scientist at ETH Zurich, studying the interaction between human and environmental systems at the Institute for Natural and Social Science Interface. In 2006, Binder joined the University of Zurich as an assistant professor in the Department of Geography, and in 2009 moved to the University of Graz in Austria where she served as a full professor of systems science. In 2011, she took a position at the University of Munich’s Department of Geography as a full professor of human-environment relations.
Binder joined EPFL in March 2016 and set up the Laboratory for Human-Environment Relations in Urban Systems (HERUS) at ENAC; she also holds the La Mobilière Chair on Urban Ecology and Sustainable Living.
Her research involves analyzing, modelling and assessing the transition of urban systems towards sustainability. She looks in particular at how we can better understand the dynamics of urban metabolism, what characterizes a sustainable city, and what drives and hinders transformation processes. She does so by combining knowledge from social, natural and data science. Her research focuses on food, energy, and sustainable living and transport in urban systems.
In Switzerland, Binder was appointed to the Research Council, Programs Division of the Swiss National Science Foundation (SNSF) in 2016 and serves on the Steering Committee of the SNSF’s National Research Program 71, “Managing Energy Consumption” and the Swiss Competence Centers for Energy Research (SCCER). She is also a member of the Steering Board on Sustainability Research for the Swiss Academies of Arts and Sciences. In 2019, she was elected as a member of the University Council of the University of Munich (LMU).
At EPFL, Binder is the academic director of Design Together, a cross-disciplinary teaching initiative. She was appointed to the management team of the Energy Center in 2018 and as head of the working group on EPFL’s energy and sustainability strategy in 2019.
Marc GruberAdministrative & Editorial Positions
2017- Vice President for Innovation at EPFL
2013- Deputy & Associate Editor: Academy of Management Journal (AMJ
2009-2016 Director of the MTE Master Program at EPFL
2000-2005 Manager of the LMU Entrepreneurship Center
Academic Positions
10/2005 - present
Ecole Polytechnique Fédérale de Lausanne (EPFL)
Assistant Professor (2005-2008), Associate Professor (2008-2010), Full Professor (since 2011)
9/2004 -12/2004
Wharton School, University of Pennsylvania, Philadelphia
Visiting Scholar
9/2000 - 9/2005
University of Munich (LMU), Munich School of Management
Habilitand
Vice-Director of the Institute for Innovation Research, Technology Management and Entrepreneurship (Director: Prof. Dietmar Harhoff, Ph.D.)
Manager of the ODEON Center for Entrepreneurship
1/1999 -12/1999
Wharton School, University of Pennsylvania, Philadelphia
Visiting Scholar
10/1995-12/1998
University of St. Gallen, HSG
Research Assistant, Ph.D. candidate
Degrees and Nominations
4/2005 University of Munich (LMU), Munich School of Management
Venia Legendi for Management (Habilitation)
10/2000 University of St. Gallen, HSG
Ph.D. in Management
10/1995 University of St. Gallen, HSG
Master in Business Administration (lic. oec. HSG)
Pierre VandergheynstPierre Vandergheynst received the M.S. degree in physics and the Ph.D. degree in mathematical physics from the Université catholique de Louvain, Louvain-la-Neuve, Belgium, in 1995 and 1998, respectively. From 1998 to 2001, he was a Postdoctoral Researcher with the Signal Processing Laboratory, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland. He was Assistant Professor at EPFL (2002-2007), where he is now a Full Professor of Electrical Engineering and, by courtesy, of Computer and Communication Sciences. As of 2015, Prof. Vandergheynst serves as EPFL’s Vice-Provost for Education. His research focuses on harmonic analysis, sparse approximations and mathematical data processing in general with applications covering signal, image and high dimensional data processing, computer vision, machine learning, data science and graph-based data processing. He was co-Editor-in-Chief of Signal Processing (2002-2006), Associate Editor of the IEEE Transactions on Signal Processing (2007-2011), the flagship journal of the signal processing community and currently serves as Associate Editor of Computer Vision and Image Understanding and SIAM Imaging Sciences. He has been on the Technical Committee of various conferences, serves on the steering committee of the SPARS workshop and was co-General Chairman of the EUSIPCO 2008 conference. Pierre Vandergheynst is the author or co-author of more than 70 journal papers, one monograph and several book chapters. He has received two IEEE best paper awards. Professor Vandergheynst is a laureate of the Apple 2007 ARTS award and of the 2009-2010 De Boelpaepe prize of the Royal Academy of Sciences of Belgium.
Florence Graezer BideauSenior Lecturer and Senior Scientist at the College of Humanities and at the School of Architecture, EPFLVisiting Professor at the Department of Architecture and Design, Politecnico di Torino PhD in History and Civilization (EHESS, Paris) Director of the Minor in Area and Cultural Studies (MACS) between 2012 and 2016Member of the Research group Heritage, culture and the cityAssociated researcher at the China Room Research Group and South China-Torino Collaboration Lab, Politecnico di Torino Associate member of the Laboratoire d’anthropologie culturelle et sociale (LACS), UNIL Member of the EDAR committee (Doctoral Program Architecture and Sciences of the City) at the School of Architecture, Civil and Environment Engineering in EPFL Florence Graezer Bideau trained as an anthropologist and a sinologist, and received her PhD in History and Civilization in 2005. Before joining the Centre for Area and Cultural Studies (CACS) at EPFL in 2010, she was a lecturer in anthropology at the University of Lausanne, where she taught courses in cultural theory and fieldwork methodology. She is Senior Lecturer and Senior Scientist at the College of Humanities where she teaches area studies, anthropology of China, critical heritage studies and urban studies. She has been acting as Director of the Minor in Area and Cultural Studies between 2012 and 2016 and she is currently a member of the EDAR committee (Doctoral Program Architecture and Sciences of the City) at the School of Architecture, Civil and Environment Engineering in EPFL. Since 2015, Florence has also been Visiting Professor at the Department of Architecture and Design, Politecnico di Torino, Italy. Her fields of expertise include anthropology of China, urban sociology, modes of sociability and governmentality. Florence’s research is on the relation between culture and power (making of cultural policy in China; emergence of maker movement (makerspaces) and politics of innovation in China), heritage issues (process of heritagization and multiculturalism in Malaysia and Singapore; implementation of the UNESCO Convention for Safeguarding Intangible Cultural Heritage in Switzerland; historic urban landscape in heritage policy of Beijing, Rome and Mexico City), and the making of the city (informal resistances toward the violence of urbanism in Caracas, Chennai and Guangzhou; uses of public spaces in Chinese new towns).
Simon Elias BibriExpertise
• Sustainable cities• Smarter eco-cities• Sustainable smart cities• Artificial Intelligence of Things (AIoT) • Generative Artificial Intelligence of Things (GAIoT)• Foundation Models (FMs) • Quantum Generative Artificial Intelligence (QGAI)• Urban Digital Twins (UDTs)• Urban Brain (UB) • Smart Circular Metabolism• Urban planning and design• Environmental sustainability and climate resilience• Sustainable smart energy• Sustainable smart transportation• Sustainable smart waste and water management•
Maher KayalMaher Kayal received M.S. and Ph.D degrees in electrical engineering from the Ecole Polytechnique Fédérale de Lausanne (EPFL, Switzerland) in 1983 and 1989 respectively. He has been with the Electronics laboratories of the Ecole Polytechnique Fédérale de Lausanne (EPFL, Switzerland) since 1990, where he is currently a professor and director of the Energy Management and Sustainability" section. He has published many scientific papers, coauthor of three text books dedicated to mixed-mode CMOS design and he holds eleven patents. His technical contributions have been in the area of analog and Mixed-signal circuits design including highly linear and tunable sensors microsystems, signal processing and green energy management.
Prizes and Honors
Electronics Letters journal Premium Award 2013,
Outstanding Paper Award? IEEE Mixdes 2013
Basil Papadias paper Award, IEEE Powertech 2013
Best Paper Awards, Mixdes 2013
Best Paper Awards, ICCAS 2012
Outstanding Paper Award- IEEE Mixdes 2012.
Poland Section IEEE ED Chapter special award in 2011.
Credit Suisse Award for Best Teaching- 2009.
The William M. Portnoy Award at the Energy Conversion Congress and Exposition , California Sept 2009.
Best Paper Award - IEEE-Mixdes 2009.
High Quality Paper - IEEE Power Tech Conference June 2009.
Best Paper Award - IEEE-Mixdes 2007.
Best Paper Award - IEEE-TTTC International Conference on Automation, Quality and Testing, Robotics - 2006.
Best Application Specific Integrated Circuit at the International European Design and Test Conference ED&TC - 1997.
Ascom Award for the Best Work in Telecommunication Fields 1990.
Publications Books.
Books:
Methodology for the Digital Calibration of Analog Circuits and Systems, Marc Pastre & Maher Kayal. Springer Publisher- (ISBN 1-4020-4252-3)-2006.
Structured Analog CMOS Design, Danica Stefanovic & Maher Kayal. Springer Publisher-(ISBN 978-1-4020-8572-7)-2008.
Linear CMOS RF Amplifiers for Wireless Applications, Maher Kayal, Springer Publisher. (ISBN 978-90-481-9360-8)-2010.
Coeditor of Microelectronics Education Kluwer Academic Publishers. (ISBN 1-4020-2072-4). -2004.
