Fasting

Fasting is the abstention from eating and sometimes drinking. From a purely physiological context, "fasting" may refer to the metabolic status of a person who has not eaten overnight (see "Breakfast"), or to the metabolic state achieved after complete digestion and absorption of a meal. Metabolic changes in the fasting state begin after absorption of a meal (typically 3–5 hours after eating). A diagnostic fast refers to prolonged fasting from 1 to 100 hours (depending on age) conducted under observation to facilitate the investigation of a health complication, usually hypoglycemia. Many people may also fast as part of a medical procedure or a check-up, such as preceding a colonoscopy or surgery, or before certain medical tests. Intermittent fasting is a technique sometimes used for weight loss that incorporates regular fasting into a person's dietary schedule. Fasting may also be part of a religious ritual, often associated with specifically scheduled fast days, as determined by the religion. Starvation responseIntermittent fastingAutophagy and Fasting and longevity Fasting may have different results on health in different circumstances. To understand whether loss of appetite (anorexia) during illness was protective or detrimental, researchers in the laboratory of Ruslan Medzhitov at Yale School of Medicine gave carbohydrate to mice with a bacterial or viral illness, or deprived them of carbohydrate. They found that carbohydrate was detrimental to bacterial sepsis. But with viral sepsis or influenza, nutritional supplementation with carbohydrates was beneficial, decreasing mortality, whereas denying glucose to the mice, or blocking its metabolism, was lethal. The researchers put forth hypotheses to explain the findings and called for more research on humans to determine whether our bodies react similarly, depending on whether an illness is bacterial or viral.