Concept

Fragment-based lead discovery

Related lectures (32)

Delves into the fundamentals of medicinal chemistry, emphasizing the interrogation of Structure-Activity Relationships (SAR) in drug design.

Fragment-Based Drug Discovery: Concepts & Technologies

Covers the concepts and technologies of fragment-based drug discovery, exploring hit identification, lead optimization, and screening methods.

Small Molecule Drugs: Genetic Diseases

Delves into the molecular basis of genetic diseases, discussing specific examples like Phenylketonuria and Haemophilia A, and the development of small molecule drugs for genetic disorders.

Space 4 Healthcare: Microgravity Applications in Biotechnology MOOC: New Space Economy

Delves into microgravity applications in biotechnology, addressing challenges on Earth and the potential solutions offered by space production.

Mapping Local Proteome Responsivity

Explores mapping local proteome responsivity through chemical actionability, precision electrophile delivery, and spatial proteomics technologies.

Precision Electrophile Signaling: Tools for Unconventional Codes

Presents T-REX, a method for studying electrophile signaling in vivo and its applications in live cells and animal models.

Drug Discovery: Computational Approaches

Explores the EXSCALATE4COV project, focusing on computational drug discovery for COVID-19 treatments and the collaboration between academia and industry.

DNA-Encoded Libraries

Explores DNA-encoded libraries for drug discovery, covering synthesis techniques, pros and cons, and diverse DEL methods.

Cyclic Peptides and Macrocycles

Explores cyclic peptides and macrocycles, their applications in drug development, and the role of bicyclic peptides in targeting specific proteins.

Deep Generative Models in Drug Discovery

Explores the application of deep generative models in drug discovery, focusing on designing small molecules and optimizing molecular structures.

Introduction: small molecule drugs for cancer

Introduces small molecule drugs for cancer treatment, covering drug discovery, mechanisms of action, and historical development of anti-cancer agents.

Quantitative Proteome Profiling: Chemical Target Identification

Explores quantitative proteome profiling for drug target identification through activity-based protein profiling and advanced mass spectrometry techniques.

Drug Target Discovery: Thermal Shift Profiling

Covers drug target discovery through stability shifts and proteomics with isobaric tags.

Malaria: Cancer Therapies Against GHI

Explores the mechanisms controlling parasite proliferation and the search for novel anti-malarial drugs.

The ClpXP Proteolytic Complex: Basic Principles to Drug Discovery

Explores the ClpXP proteolytic complex, its drug targeting potential, and antimicrobial applications through compound screening.

Infectious Diseases: Small Molecule Drugs

Explores small molecule drugs for infectious diseases, covering global mortality rates, viral and bacterial injuries, antiviral and antibacterial agents, and the development of COX2 inhibitors.

Enantioselective C-H Activation

Explores enantioselective C-H activation reactions using Cu, Rh, and Ni catalysts for functionalization of olefins, alkynes, and alkenes.

Protein-Ligand Interactions

Explores the principles of protein-ligand interactions, covering methods for measuring affinity and kinetics in drug development.

Small Molecule Drugs: Cardiovascular Diseases

Explores the molecular basis and treatment of cardiovascular diseases, focusing on atherosclerosis, hypertension, and drug therapies.

Micro-ElectroMechanical Systems (MEMS)

Explores Micro-ElectroMechanical Systems (MEMS) development, ion channels, patch clamp technique, drug discovery, and PDMS integration in microfluidic systems.

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