Thomas La GrangeExpertise
Electron Microscopy, Aberration Correct Scanning Transmission Electron Microscopy, Electron Diffraction, Ultrafast Transmission Electron Microscopy, Electron Energy Loss Spectroscopy, Energy Dispersive Spectroscopy, Materials Science, High-speed deformation, Dislocation Dynamics, Skyrmionics, Martensitic Phase Transformation Theory, Solidification
Expertise
Electron Microscopy, Aberration Correct Scanning Transmission Electron Microscopy, Electron Diffraction, Ultrafast Transmission Electron Micro
Nicolas MacrisNicolas Macris received the PhD degree in theoretical physics from EPFL and then pursued his scientific activity at the mathematics department of Rutgers University (NJ, USA). He then joined the Faculty of Basic Science of EPFL, working in the field of quantum statistical mechanics and mathematical aspects of the quantum Hall effect. Since 2005 he is with the Communication Theories Laboratory and Information Processing group of the School of Communication and Computer Science and currently works at the interface of statistical mechanics, information theory and error correcting codes, inference and learning theory. He held long-term visiting appointments and collaborations with the University College and the Institute of Advanced studies in Dublin, the Ecole Normale Supérieure de Lyon, the Centre de Physique Theorique Luminy Marseille, Paris XI Orsay, the ETH Zürich and more recently Los Alamos National Lab. CV and publication list.
Rüdiger UrbankeRüdiger L. Urbanke obtained his Dipl. Ing. degree from the Vienna University of Technology, Austria in 1990 and the M.Sc. and PhD degrees in Electrical Engineering from Washington University in St. Louis, MO, in 1992 and 1995, respectively. He held a position at the Mathematics of Communications Department at Bell Labs from 1995 till 1999 before becoming a faculty member at the School of Computer & Communication Sciences (I&C) of EPFL. He is a member of the Information Processing Group. He is principally interested in the analysis and design of iterative coding schemes, which allow reliable transmission close to theoretical limits at low complexities. Such schemes are part of most modern communications standards, including wireless transmission, optical communication and hard disk storage. More broadly, his research focuses on the analysis of graphical models and the application of methods from statistical physics to problems in communications. From 2000-2004 he was an Associate Editor of the IEEE Transactions on Information Theory and he is currently on the board of the series "Foundations and Trends in Communications and Information Theory." In 2017 he was President of the Information Theory Society. From 2009 till 2012 he was the head of the I&C doctoral school, in 2013 he served as Dean a. i. of I&C, and since 2016 he is the Associated Dean for teaching of I&C. He is a co-author of the book "Modern Coding Theory" published by Cambridge University Press. Awards: 2021 IEEE Information Theory Society Paper Award 2016 STOC Best Paper Award 2014 La Polysphere Teaching Award 2014 IEEE Hamming Medal 2013 IEEE Information Theory Society Paper Award 2011 MASCO Best Paper Award 2011 IEEE Koji Kobayashi Award 2009 La Polysphere Teaching Award 2002 IEEE Information Theory Society Paper Award Fulbright Scholarship My students have won the following awards: M. Mondelli, 2021 IEEE Information Theory Paper Award M. Mondelli, EPFL Doctorate Award 2018 M. Mondelli, Patrick Denantes Award, 2017 M. Mondelli, IEEE IT Society Student Paper Award at ISIT, 2015 M. Mondelli, Dan David Prize Scholarship, 2015 H. Hassani, Inaugural Thomas Cover Dissertation Award, 2014 S. Kudekar, 2013 & 2021 IEEE Information Theory Paper Award A. Karbasi, Patrick Denantes Award, 2013 V. Venkatesan, Best Paper Award at MASCOTS, 2011 A. Karbasi, Best Student Paper Award at ICASSP, 2011 (with R. Parhizkar) A. Karbasi, Best Student Paper Award at ACM SIGMETRICS, 2010 (with S. Oh) S. Korada, ABB Dissertation Award, 2010 S. Korada, IEEE IT Society Student Paper Award at ISIT, 2009 (with E. Sasoglu) S. Korada, IEEE IT Society Student Paper Award at ISIT, 2008
Michaël UnserExpertise
Image Processing, Medical Imaging, Biological Imaging, Wavelets, Splines, Multiresolution
Michael Unser is Full Professor with EPFL’s school of Engineering and the academic director of EPFL's Center for Imaging, Lausanne, Switzerland. His primary areas of investigation are signal processing, biomedical imaging and applied functional analysis. He is internationally recognized for his research contributions to sampling theory, wavelets, the use of splines for image processing, stochastic processes,
Daniel SageExpertise
PublicationsPublications
Coordinates Biomedical Imaging GroupAddressEPFL STI-IMT-LIB, BM 4.135, Station 17, CH-1015 Lausanne, SwitzerlandTel.+41 21 693 51 89Fax.+41 21 693 68 10Emaildaniel.sage@epfl.chWeb pagehttp://bigwww.epfl.ch/sage/OfficeBM 4.135
Teaching & PhD Past EPFL PhD Students as codirector Daniel Andreas Schmitter, Anaïs Badoual, Laurène Donati Courses Bioimage informatics BIO-410 The course provides a comprehensive overview of methods, algorithms, and computer tools us Olexiy KochubeyTeaching & PhD PhD Students Nishant Jana Past EPFL PhD Students as codirector Aiste Baleisyte, Denys Osypenko Courses Neural circuits of motivated behaviors BIO-499 Motivated behaviors fulfil the basic physiological needs of animals and enable their safety. In this course, you will learn about the neuronal circuits that sense and regulate internal states, detect dangers in the environment, and organize appropriate behavioral responses.
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
