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Concept

Lactic acid

Related publications (31)

Additive and digital manufacturing of transient sensors and bioelectronics

Nicolas Francis Fumeaux

Transient electronics have emerged as a promising class of devices, capable of breaking down without harmful side effects to their environment. They have tremendous potential as bioresorbable electronics for temporary applications in the human body, and as ...

EPFL2023

Biocompatible and Biodegradable 3D Printing from Bioplastics: A Review

Sandro Carrara

There has been a lot of interest in developing and producing biodegradable polymers to address the current environmental problem caused by the continued usage of synthetic polymers derived from petroleum products. Bioplastics have been identified as a poss ...

MDPI2023

Photodegradation of biodegradable plastics in aquatic environments: Current understanding and challenges

Florian Frédéric Vincent Breider

Direct photolysis and indirect photolysis are important abiotic processes in aquatic environments through which plastics can be transformed physically and chemically. Transport of biodegradable plastics in water is influenced by vertical mixing and turbule ...

2023

Early Neuroprotective Effects of Bovine Lactoferrin Associated with Hypothermia after Neonatal Brain Hypoxia-Ischemia in Rats

Yohan Van de Looij, Analina Raquel Hausin

Neonatal hypoxic-ischemic (HI) encephalopathy (HIE) in term newborns is a leading cause of mortality and chronic disability. Hypothermia (HT) is the only clinically available therapeutic intervention; however, its neuroprotective effects are limited. Lacto ...

MDPI2023

Tailoring the performance of nanocellulose-based multilayer-barrier paperboard using biodegradable-thermoplastics, pigments, and plasticizers

Tiffany Abitbol

In this work a multilayer barrier paperboard was produced in a roll-to-roll process by slot-die coating of nanocellulose (microfibrillated cellulose or carboxymethylated cellulose nanofibrils) followed by extrusion coating of biodegradable thermoplastics ( ...

SPRINGER2023

Lignin, from biomass waste to sustainable materials for food packaging, antiviral coatings and agriculture

Alice Boarino

Our planet has been challenged for years by our reckless use of fossil fuels, which has led to the ongoing climate change and energy crisis. The transition to the use of renewable alternative sources has now became urgent and inevitable. The valorization o ...

EPFL2023

Polyamide Nanofiber-Based Air Filters for Transparent Face Masks

Thierry Pelet

Transparent face masks are the ultimate solution for improving communication during pandemic times while at the same time slowing the spread of pathogens. Here, we demonstrate an easily scalable process consisting of directly electrospinning polyamide nano ...

AMER CHEMICAL SOC2021

Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

Rolf Gruetter, Arnaud Comment, Cristina Ramona Cudalbu Moldovan, Bernard Lanz, Mor-Miri Mishkovsky, Jocelyne Bloch

Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using standard ...

Nature Research2021

Covalent and Noncovalent Conjugation of Degradable Polymer Nanoparticles to T Lymphocytes

Harm-Anton Klok, Tanja Thomsen

Cells are attractive as carriers that can help to enhance control over the biodistribution of polymer nanomedicines. One strategy to use cells as carriers is based on the cell surface immobilization of the nanoparticle cargo. While a range of strategies ca ...

American Chemical Society2021

Evaluating the potential of hyperpolarised [1-13C] L-lactate as a neuroprotectant metabolic biosensor for stroke

Mor-Miri Mishkovsky, Jean-Noël Hyacinthe, Lara Buscemi Estefanell, Thanh Phong Kevin Lê, Mario Gaetano Lepore

Cerebral metabolism, which can be monitored by magnetic resonance spectroscopy (MRS), changes rapidly after brain ischaemic injury. Hyperpolarisation techniques boost (13)C MRS sensitivity by several orders of magnitude, thereby enabling in vivo monitoring ...

Nature Research2020

Biodegradation and Antimicrobial Properties of Zinc Oxide-Polymer Composite Materials for Urinary Stent Applications

Lorenzo Lucherini

Research advancements in the field of urinary stents have mainly been in the selection of materials and coatings to address commonly faced problems of encrustation and bacterial adhesion. In this study, polylactic acid (PLA) and polypropylene (PP) were eva ...

2020

Lactate enhancing compounds and uses thereof

Pierre Magistretti, Sylvain Eric Lengacher, Charles Léonard Finsterwald

Abstract of the invention: The present invention relates to new agents useful for stimulating release of lactate by astrocytes. The invention further relates to methods of preparation, formulations and therapeutic uses of those agents, notably for the prev ...

2020

Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized 13C magnetic resonance

Arnaud Comment, Mor-Miri Mishkovsky, Hikari Ananda Infinity Yoshihara, Nicolas Kunz, Emine Can

The metabolic shift induced in human CD4+ T lymphocytes by stimulation is characterized by an upregulation of glycolysis, leading to an augmentation in lactate production. This adaptation has already been highlighted with various techniques and reported in ...

Nature Research2020

Biochemical conversion of biodiesel by-product into malic acid: A way towards sustainability

Edgard Gnansounou

Crude glycerol, one of the ever-growing by-product of biodiesel industry and is receiving the closest review in recent times because direct disposal of crude glycerol may emerge ecological issues. The renewability, bioavailability and typical structure of ...

ELSEVIER2020

Conversion of vine shoots into bioethanol and chemicals: Prospective LCA of biorefinery concept

Edgard Gnansounou, Elia Mercedes Ruiz Pachon, Prasad Vithalrao Mandade

Vine shoots are the viticulture residues generated in high quantities after the grapevine pruning. They are lignocellulosic material poorly exploited as feedstock. These wastes are often dumped in the agriculture fields or burnt. Due to their availability ...

Elsevier2020

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Etienne Meylan

Depleting regulatory T cells (T-reg cells) to counteract immunosuppressive features of the tumor microenvironment (TME) is an attractive strategy for cancer treatment; however, autoimmunity due to systemic impairment of their suppressive function limits it ...

NATURE PUBLISHING GROUP2020

Lactate measurement by neurochemical profiling in the dorsolateral prefrontal cortex at 7T: accuracy, precision, and relaxation times

Pierre Magistretti, Lijing Xin, Masoumeh Dehghani Moghadam

Purpose This assesses the potential of measuring lactate in the human brain using three non-editing MRS methods at 7T and compares the accuracy and precision of the methods. Methods H-1 MRS data were measured in the right dorsolateral prefrontal cortex usi ...

Wiley2020

Labor division in engineered cross-kingdom consortia: Consolidated bioprocessing of lignocellulosic biomass to carboxylic acids

Robert Lawrence Shahab

Lignocellulose is a renewable source of fixed carbon and a promising substrate for the production of chemicals and fuels in second generation biorefineries. In this thesis, we engineered artificial microbial consortia for consolidated bioprocessing (CBP) o ...

EPFL2019

3D spacers enhance flow kinetics in resin transfer molding with woven fabrics

Véronique Michaud, Baris Çaglar, Damiano Salvatori

Impregnation time in Resin Transfer Molding (RTM) is directly proportional to resin viscosity and inversely proportional to fabric permeability, limiting the use of high-viscosity resins with conventional reinforcements. In this study, we show how to reduc ...

2019

Recent advances in microbial production of malic acid from renewable byproducts

Edgard Gnansounou

In the last few years, ecofriendly malic acid production has received a potential platform for the bio-based chemicals to replace the dependency of fossil based resources. The main goal of this paper is to explore the feasibility of efficient production of ...

SPRINGER2019