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Concept

Genetic load

Related publications (22)

Non-Darwinian dynamics in therapy-induced cancer drug resistance

Andreas Eduard Moor

The development of drug resistance, the prime cause of failure in cancer therapy, is commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-genetic heterogeneity of clonal cell populations continuously produces metastabl ...

Nature Publishing Group2013

Competing islands limit the rate of adaptation in structured populations

Cornelia Pokalyuk

Beneficial mutations can co-occur when population structure slows down adaptation. Here, we consider the process of adaptation in asexual populations distributed over several locations ("islands"). New beneficial mutations arise at constant rate u(b), and ...

Elsevier2013