Rolf GruetterAwards:
1999 Young Investigator Award Plenary Lectureship
, International Society for Neurochemistry
2011 Fellow
, ESMRMB
2011 Teaching Award
, Section Sciences de la Vie, EPFL
Raphaël DoenlenEducation Master | Neurosciences 2004 – 2004 University of Louis Pasteur, Strasbourg (France) Master | Psycho-pharmacology 2005 – 2005 University of Bordeaux 1 (France) PhD | Life Sciences - Neuro-immunology 2005 – 2008 Swiss Federal Institute of Technology, ETH Zürich (Switzerland) Directed by Principal supervisor: Prof. Joram Feldon, Institute of Behavioural Neurobiology, ETH Zürich (Switzerland)Co-supervisor: Prof. Manfred S
Isabelle Barbara Marie-Hélène CardiaCandidature à l’AE et au Conseil de faculté
To motivate my engagement within the School Assembly and the Faculty Council, I would like to highlight my background and experience at EPFL. With fourteen years of experience within the institution, an intentionally atypical professional trajectory, and a background in the humanities, I bring a transversal and original perspective that I am keen to place at the service of the School Assembly and the STI Faculty.Throughout my career at EPFL, I have held administra
Denis GilletDenis Gillet received the Diploma in Electrical Engineering from the Swiss Federal Institute of Technology in Lausanne (EPFL) in 1988, and the Ph.D. degree in Information Systems also from the EPFL in 1995. During 1992 he was appointed as Research Fellow at the Information Systems Laboratory of Stanford University in the United States. He is currently Maître d'enseignement et de recherche at the EPFL School of Engineering, where he leads the React research group. His current research interests include Technologies Enhanced Learning (TEL), Human Computer Interaction (HCI), Human Devices Interaction (HDI) and Optimal Coordination of Complex and Distributed Systems. Denis Gillet is affiliated at EPFL with the Center for Intelligent Systems and the Center for Digital Education.
Johan AuwerxJohan Auwerx is Professor at the École Polytechnique Fédérale in Lausanne, Switzerland, where he occupies the Nestle Chair in Energy Metabolism. Dr. Auwerx has been using molecular physiology and systems genetics to understand metabolism in health, aging and disease. Much of his work focused on understanding how diet, exercise and hormones control metabolism through changing the expression of genes by altering the activity of transcription factors and their associated cofactors. His work was instrumental for the development of agonists of nuclear receptors - a particular class of transcription factors - into drugs, which now are used to treat high blood lipid levels, fatty liver, and type 2 diabetes. Dr. Auwerx was amongst the first to recognize that transcriptional cofactors, which fine-tune the activity of transcription factors, act as energy sensors/effectors that influence metabolic homeostasis. His research validated these cofactors as novel targets to treat metabolic diseases, and spurred the clinical use of natural compounds, such as resveratrol, as modulators of these cofactor pathways.
Johan Auwerx was elected as a member of EMBO in 2003 and is the recipient of a dozen of international scientific prizes, including the Danone International Nutrition Award, the Oskar Minkowski Prize, and the Morgagni Gold Medal. His work is highly cited by his peers with a h-factor of over 100. He is an editorial board member of several journals, including Cell Metabolism, Molecular Systems Biology, The EMBO Journal, Journal of Cell Biology, Cell, and Science. Dr. Auwerx co-founded a handful of biotech companies, including Carex, PhytoDia, and most recently Mitobridge, and has served on several scientific advisory boards.
Dr. Auwerx received both his MD and PhD in Molecular Endocrinology at the Katholieke Universiteit in Leuven, Belgium. He was a post-doctoral research fellow in the Departments of Medicine and Genetics of the University of Washington in Seattle.
Jean-Marc OdobezExpertise
Computer Vision, machine Learning (Bayesian models, deep learning), multimodal processing.Activity analysis, human behavior understanding, human communication, interaction modeling
Dr Jean-Marc Odobez (Msc 1990, PhD 1994) received his Ph.D degree from Rennes University in 1994 for his PhD dissertation done at INRIA. After 5 years as an assistant professor at the University du Maine, France, he decided to join Idiap, where he is now the Head of the Perception & Activity Understanding Group and adju
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Simone AstoriTeaching & PhD Past EPFL PhD Students as codirector Silvia Monari, Alessandro Chioino, Loredana Cumpana
Simon Nessim HeneinBorn in 1973 and of Egyptian-Swiss nationality, Simon Henein grew up in Cairo. He obtained an engineering degree at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in 1996 and went on to complete his doctorate at the EPFL in 2000. In 2001, he published the book “Conception des guidages flexibles” which has become a reference in precision engineering. He then joined the Centre Suisse d’Electronique et Microtechnique (CSEM), Neuchatel, Switzerland, where he conceived and developed mechanisms for robotic, aerospace, medical and watchmaking applications. He pursued his research career at the Paul Scherrer Institute, Villigen, Switzerland, where he developed instruments for the Swiss Light Source Synchrotron (SLS). Since November 1st, 2012, he is associate professor in microengineering at the EPFL, holder of the Patek Philippe Chair and director of the Micromechanical and horological design laboratory (Instant-Lab).
Eduardo Martin MoraudExpertise
The Moraud group develops closed-loop neuromodulation therapies for movement disorders, particularly Parkinson’s disease, with a specific emphasis on gait and balance impairments. The group integrates multimodal monitoring of motor and neural biomarkers to enable real-time decoding of dysfunctional states and their underlying neural dynamics, advancing a circuit-level understanding of locomotor control and informing the design of state-dependent adaptive therapies.
Mission
The group aims to transl
Kamiar AminianKamiar Aminian received the M.S. degree in electrical engineering in 1982, the Ph.D degree in biomedical engineering in 1989 and the Postgraduate degree on technical computing in 1993 from Ecole Polytechnique Fédérale de Lausanne (EPFL). He was assistant professor (1994-1996) with Sharif University of Technology (Tehran). He joint EPFL in 1996 where he is currently Professor of medical instrumentation and the director of the Laboratory of Movement Analysis and Measurement in the Institute of Bioengineering of EPFL. His research interests include methodologies for human movement monitoring and analysis in real world conditions mainly based on wearable technologies and inertial sensors with emphasis on gait, physical activity and sport. His research aims to perform outcome evaluation in orthopaedics, to improve motor function and intervention programs in aging and patients with movement disorders and pain, and to identify metrics of performance in sport science.
Kamiar Aminian is a member of the International Society of Posture and Gait Research, the Institute of Electrical and Electronics Engineers, the European Society of Movement Analysis in Adults and Children, the Prevention of fall Network Europe, the Intentional Society of Biomechanics and the President of the 3D analysis of the human movement group. He is author or co-author of more than 450 scientific papers published in reviewed journals and presented at international conferences and holds 10 patents related to medical devices.
Full CV
ORCID
Fosco Bernasconi2014-Present:
post-doc at the EPFL, Laboratory of Congitive Neuroscience.
2012-2014:
Postdoctoral Research Associate, Charité University Medicine, Berlin, Germany.
2012:
Postdoctoral Research Associate,Psychiatric University Hospital (PUK), Zurich, Switzerland.
2008-2011:
PhD in Neurosciences,Lemanic Neurosciences Doctoral School, Faculty of Biology and Medicine, Lausanne University, Switzerland.
2007-2008:
Master in Medical Biology,Faculty of Biology & Medicine, Lausanne University,Switzerland.
Stewart ColeProfessor Stewart Cole is an international authority in bacterial molecular-genetics and genomics. He has made outstanding contributions in several fields including: bacterial anaerobic electron transport; genome analysis of retroviruses and papillomaviruses; antibiotic resistance mechanisms; and the molecular microbiology of toxigenic clostridia. His studies on isoniazid and multidrug resistance in Mycobacterium tuberculosis, together with his pioneering work on the pathogenicity, evolution and genomics of the tubercle and leprosy bacilli, have made him an undisputed leader in the field of mycobacterial research. The findings of his research are of direct relevance to public health and disease-control in both the developing world and the industrialised nations. He has published over 250 scientific papers and review articles, and holds many patents.
Loïc Jean Pierre HerviouTeaching & PhD Courses Solid state physics III PHYS-419 The aim of this course is to provide an introduction to the theory of a few remarkable phenomena of modern condensed matter physics ranging from the quantum Hall effects to superconductivity.
Ian SmithPhD, Cambridge University, 1982 Interests 1 Active shape control for structures for deployment and where serviceability criteria governs 2 Biomimetic structures (learning, self-diagnosis, self-repair) 3 Infrastructure management support through structural identification 4 Advanced computer-aided engineering applications of stochastic optimization and search, multi-criteria analysis, system uncertainties (measurement and modelling), multi-modal approaches (combining statistics with behavior models) More details : see https://www.epfl.ch/labs/imac/research/iansmith/ Frédéric MilaExpertise
Condensed matter theory, strongly correlated systems, frustrated and quantum magnetism, tensor networks
Mission
Perform research in condensed matter theory, whenever possible in collaboration with experimentalists at EPFL and throughout the world
Current Work
- Magnetism on the Shastry-Sutherland lattice- Tensor network approach to 2D strongly correlated systems- Thermal properties of 2D frustrated quantum magnets- Exotic phases of quantum one-dimensional models
Since 2003 Full Professor at EPFL (
