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Concept

Environmental toxicology

Related publications (12)

Evaluation of tire tread particle toxicity to fish using rainbow trout cell lines

Kristin Schirmer, Florian Frédéric Vincent Breider, Benoît Jean Dominique Ferrari, Thibault Béranger Masset, Gabrielle Léger

Tire and road wear particles (TRWP) resulting from tire abrasion while driving raise concerns due to their potential contribution to aquatic toxicity. Our study aimed to assess cryogenically milled tire tread (CMTT) particle toxicity, used as a proxy for T ...

2023

Bioaccessibility of Organic Compounds Associated with Tire Particles Using a Fish In Vitro Digestive Model: Solubilization Kinetics and Effects of Food Coingestion

Kristin Schirmer, Florian Frédéric Vincent Breider, Dominique Grandjean, Benoît Jean Dominique Ferrari, Thibault Béranger Masset, Luke Christopher Harris

Tire and road wear particles (TRWP) account for an important part of the polymer particles released into the environment. There are scientific knowledge gaps as to the potential bioaccessibility of chemicals associated with TRWP to aquatic organisms. This ...

2022

Adsorption of progesterone onto microplastics and its desorption in simulated gastric and intestinal fluids

Florian Frédéric Vincent Breider, Dominique Grandjean, Thibault Béranger Masset, Cécilia Laetitia Carla Siri

The sorption of Hydrophobic Organic Compound (HOC) onto microplastics is relatively well reported in the literature, while their desorption remains poorly investigated, and especially in biological ﬂuids. The present study investigated the sorption and des ...

2021

Ultrathin Alumina Membranes as Scaffold for Epithelial Cell Culture from the Intestine of Rainbow Trout

Philippe Renaud, Songmei Wu, Kristin Schirmer, Carolin Drieschner

Permeable membranes are indispensable for in vitro epithelial barrier models. However, currently available polymer-based membranes are low in porosity and relatively thick, resulting in a limited permeability and unrealistic culture conditions. In this stu ...

Amer Chemical Soc2017

Mercury tissue residue approach in Chironomus riparius: Involvement of toxicokinetics and comparison of subcellular fractionation methods

Along with the growing body of evidence that total internal concentration is not a good indicator of toxicity, the Critical Body Residue (CBR) approach recently evolved into the Tissue Residue Approach (TRA) which considers the biologically active portion ...

Elsevier Science Bv2016

Investigating Alternatives To The Fish Early-Life Stage Test: A Strategy For Discovering And Annotating Adverse Outcome Pathways For Early Fish Development

Kristin Schirmer

The fish early-life stage (FELS) test (Organisation for Economic Co-operation and Development [OECD] test guideline 210) is the primary test used internationally to estimate chronic fish toxicity in support of ecological risk assessments and chemical manag ...

Wiley-Blackwell2014

Systems Toxicology Approach to Understand the Kinetics of Benzo(a)pyrene Uptake, Biotransformation, and DNA Adduct Formation in a Liver Cell Model

Kristin Schirmer

Cell-based models are important for deriving mechanistic information about stress response pathways that have evolved to protect cells from toxic insult, such as exposure to environmental pollutants. One determinant of the stress response is the amount of ...

Amer Chemical Soc2014

Bioavailability of inorganic nanoparticles to planktonic bacteria and aquatic microalgae in freshwater

Paul Bowen, Nadia Rachel Von Moos

Over the past few years, engineered nanomaterials (ENMs) have penetrated nearly every sector of modern life and their broad-scale use is steadily and rapidly increasing. The (expected) elevated levels of ENMs in the environment raise concerns with regard t ...

Royal Soc Chemistry2014

A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment

Kristin Schirmer

Tests with vertebrates are an integral part of environmental hazard identification and risk assessment of chemicals, plant protection products, pharmaceuticals, biocides, feed additives and effluents. These tests raise ethical and economic concerns and are ...

Academic Press Inc Elsevier Science2013

USEtox-the UNEP-SETAC toxicity model: recommended characterisation factors for human toxicity and freshwater ecotoxicity in life cycle impact assessment

Jérôme Payet

Background, aim and scope In 2005, a comprehensive comparison of life cycle impact assessment toxicity characterisation models was initiated by the United Nations Environment Program (UNEP)-Society for Environmental Toxicology and Chemistry (SETAC) Life Cy ...

2008

Risk and regulatory hazard-based toxicological effect indicators in life-cycle assessment (LCA)

In life-cycle assessment (LCA), it is desirable to compare quantities of chemicals released into the environment in terms of the risk and consequences of toxicological effects. Many current methods rely directly on adaptations of regulatory-orientated appr ...

Taylor & Francis2006

Multimedia fate and human intake modeling: Spatial versus nonspatial insights for chemical emissions in Western Europe

Multimedia fate and multipathway human,exposure models are widely adopted in assessments of toxicological risks of chemical emissions at the regional scale. This paper addresses the question of how much spatial detail is necessary in such models when estim ...

2005