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Concept

Tendon

Related publications (26)

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation

Hilal Lashuel, Annalisa Ansaloni, Sophie Vieweg, John Blaine Warner IV

The first exon of the Huntingtin protein (Httex1) is one of the most actively studied Htt fragments because its overexpression in R6/2 transgenic mice has been shown to recapitulate several key features of Huntington disease. However, the majority of bioph ...

Amer Soc Biochemistry Molecular Biology Inc2016

Concentration-dependent and surface-assisted self-assembly properties of a bioactive estrogen receptor alpha-derived peptide

Giovanni Dietler, Francesco Simone Ruggeri

We have synthesized a 17-mer peptide (ER17p) that is issued from the hinge region of the estrogen receptor and which activates the proliferation of breast carcinoma cells in steroid-deprived conditions. In the present paper, we show that at a concentration ...

Wiley-Blackwell2015

Effect of Patient Specific Parameters on Degenerative Shoulder Diseases

Christoph Anselm Engelhardt

Osteoarthritis and rotator cuff tears are two common and wide spread shoulder diseases leading to significant restrictions in the daily life of the affected. The pathogenesis is not fully understood yet. A chronic process triggered by multiple causes is as ...

EPFL2015

MOVING ALONG In biomechanics, rehabilitation engineering, and movement analysis, Italian researchers are making great strides

Silvestro Micera

In Italy, biomechanics research and the analysis of human and animal movement have had a very long history, beginning with the exceptional pioneering work of Leonardo da Vinci. In 1489, da Vinci began investigating human anatomy, including an examination o ...

Ieee-Inst Electrical Electronics Engineers Inc2015

Fluid-structure interaction simulations of cerebral arteries modeled by isotropic and anisotropic constitutive laws

Alfio Quarteroni, Simone Deparis, Luca Dede', Paolo Tricerri

This paper considers numerical simulations of fluid-structure interaction (FSI) problems in hemodynamics for idealized geometries of healthy cerebral arteries modeled by both nonlinear isotropic and anisotropic material constitutive laws. In particular, it ...

Springer Verlag2015

Structural differences of amyloid-beta fibrils revealed by antibodies from phage display

Hilal Lashuel, Patrick Droste

Background: Beside neurofibrillary tangles, amyloid plaques are the major histological hallmarks of Alzheimer's disease (AD) being composed of aggregated fibrils of beta-amyloid (A beta). During the underlying fibrillogenic pathway, starting from a surplus ...

Biomed Central Ltd2015