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Related publications (25)

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Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells

Yann Barrandon

In hair follicles, dermal papilla (DP) and dermal sheath (DS) cells exhibit striking levels of plasticity, as each can regenerate both cell types. Here, we show that thrombin induces a phosphoinositide 3-kinase (PI3K)-Akt pathway-dependent acquisition of D ...

Company of Biologists2008

Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis

Friedrich Beermann

Phosphate and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor gene inactivated in numerous sporadic cancers, including melanomas. To analyze Pten functions in melanocytes, we used the Cre-loxP system to delete Pten specifically in mu ...

2008

Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner

Freddy Radtke, Friedrich Beermann

The Notch signaling pathway is involved in diverse biological processes such as cell fate decisions or stem cell maintenance. In this study, we assessed the role of this pathway for melanocyte development and hair pigmentation using RBP-Jkappa, Notch1, and ...

2007

Model surfaces for human hair : screening perfumes and surfactants

Mabel Maucci

The thesis describes the development of surfaces that model the surface of human hair in order to characterize the adsorption of detergents and perfumes. Three types of model surfaces were investigated consisting of (i) a self-assembled monolayer of protei ...

EPFL2006

Notch1 is essential for postnatal hair follicle development and homeostasis

Freddy Radtke, Yann Barrandon

Notch genes encode evolutionarily conserved large, single transmembrane receptors, which regulate many cell fate decisions and differentiation processes during fetal and postnatal life. Multiple Notch receptors and ligands are expressed in both developing ...

2005