Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Concept

Endophenotype

Related publications (13)

EEG microstates are a candidate endophenotype for schizophrenia

Michael Herzog, Maya Roinishvili, Christine Mohr, Patricia Figueiredo, Janir Nuno Ramos Antunes Da Cruz, Ophélie Gladys Favrod

Electroencephalogram microstates are recurrent scalp potential configurations that remain stable for around 90 ms. The dynamics of two of the four canonical classes of microstates, commonly labeled as C and D, have been suggested as a potential endophenoty ...

Nature Research2020

Neural Compensation Mechanisms of Siblings of Schizophrenia Patients as Revealed by High-Density EEG

Michael Herzog, Maya Roinishvili, Patricia Figueiredo, Albulena Jashari-Shaqiri, Janir Nuno Ramos Antunes Da Cruz, Ophélie Gladys Favrod

Visual backward masking (VBM) deficits are candidate endophenotypes of schizophrenia indexing genetic liability of the disorder. In VBM, a target is followed by a mask that deteriorates target perception. Schizophrenia patients and, to a lesser extent, the ...

2020

EEG signatures of schizophrenia: visual backward masking and microstates

Janir Nuno Ramos Antunes Da Cruz

Schizophrenia is a complex and devastating mental disorder that influences how one behaves, feels, and thinks. It affects a little less than 1 % of the world population and it is understood to be partly genetically mediated. Several genetic risk factors of ...

EPFL2019

Electrophysiological correlates of visual backward masking in patients with major depressive disorder

Michael Herzog, Maya Roinishvili, Patricia Figueiredo, Ophélie Gladys Favrod, Janir Nuno Ramos Antunes Da Cruz

Depression and schizophrenia are two psychiatric diseases with high co-morbidity. For this reason, it is important to find sensitive endophenotypes, which may disentangle the two disorders. The Shine-Through paradigm, a visual backward masking task, is a p ...

2019

Electrophysiological correlates of visual backward masking in the schizophrenia continuum

Ophélie Gladys Favrod

In visual backward masking (VBM), a target is followed by a mask. Over the past decade, a VBM task, called the Shine-Through paradigm (ST), has been shown to be a very sensitive endophenotype of schizophrenia. In the present thesis, the electrophysiologica ...

EPFL2019

Neural correlates of visual backward masking in psychosis

Michael Herzog, Maya Roinishvili, Christine Mohr, Albulena Jashari-Shaqiri, Janir Nuno Ramos Antunes Da Cruz, Ophélie Gladys Favrod

In visual backward masking (VBM), a target is followed by a mask, which deteriorates performance on the target. Schizophrenia and first episodes patients show strong behavioral deficits, reflected in strongly reduced amplitudes of the EEG as compared to co ...

2017

Cognitive markers as potential endophenotypes for schizophrenia

Michael Herzog, Maya Roinishvili

Schizophrenia is a heterogeneous disease strongly influenced by genetic predisposition. A large variety of candidate genes has been identified of which each gene, however, explains only a small proportion of the genetic risk. For this reason, stable marker ...

2016

Backward masking performance in patients with functional psychoses

Michael Herzog, Maya Roinishvili

In visual backward masking, a target is followed by a blank screen (ISI - Inter-stimulus-interval) and, then, a mask which deteriorates target processing. Schizophrenic patients show strong but complex processing deficits in visual masking compared to heal ...

2016

Schizophrenia patients and 22q11.2 deletion syndrome adolescents at risk express the same deviant patterns of resting state EEG microstates: A candidate endophenotype of schizophrenia

Michael Herzog, Dimitri Nestor Alice Van De Ville, Maya Roinishvili, Maude Schneider, Fikret Isik Karahanoglu

Schizophrenia is a complex psychiatric disorder and many of the factors contributing to its pathogenesis are poorly understood. In addition, identifying reliable neurophysiological markers would improve diagnosis and early identification of this disease. T ...

2015

Endophenotypes of schizophrenia: electrophysiological correlates of first episode patients

Michael Herzog, Maya Roinishvili, Albulena Jashari-Shaqiri, Ophélie Gladys Favrod

Schizophrenia is a heterogeneous disorder and among other symptoms, patients have important visual impairments. Visual paradigms are therefore important tools to investigate the mechanisms of schizophrenia. During the last period of the NCCR, we have chara ...

2015

Schizophrenia and visual backward masking: a general deficit of target enhancement

Michael Herzog, Maya Roinishvili

The obvious symptoms of schizophrenia are of cognitive and psychopathological nature. However, schizophrenia affects also visual processing which becomes particularly evident when stimuli are presented for short durations and are followed by a masking stim ...

Frontiers Media2013

Backward masking reveals different visual processing of schizophrenic and depressive patients

Michael Herzog, Maya Roinishvili

Visual backward masking is a very sensitive tool for studying early visual processing deficits and a reliable endophenotype of schizophrenia. Mental diseases strongly overlap in many aspects, for example, in psychopathology, cognition, and genetics. Here, ...

Pion Ltd.2012

Visual backward masking deficits in schizophrenic patients are associated with polymorphisms in the nicotinic receptor α7 subunit gene (CHRNA7)

Michael Herzog, Maya Roinishvili

Visual backward masking (BM) deficits are often proposed to be trait markers for schizophrenia revealing the genetic underpinnings of the disease. Here, we show that, indeed, masking deficits in the shine-through effect are associated with polymorphisms in ...

2010