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Concept

Immunosenescence

Related publications (31)

Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection

Nicola Harris, Julia Esser-von Bieren

Over 25% of the world's population are infected with helminth parasites, the majority of which colonise the gastrointestinal tract. However, no vaccine is yet available for human use, and mechanisms of protective immunity remain unclear. In the mouse model ...

Public Library of Science2015

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

Freddy Radtke, Ute Koch, Nicolas Fasnacht

Fibroblast-like cells of secondary lymphoid organs (SLO) are important for tissue architecture. In addition, they regulate lymphocyte compartmentalization through the secretion of chemokines, and participate in the orchestration of appropriate cell-cell in ...

Rockefeller University Press2014

Diffusion on Demand to Control Precipitation Aging: Application to Al-Mg-Si Alloys

William Curtin

We demonstrate experimentally that a part-per-million addition of Sn solutes in Al-Mg-Si alloys can inhibit natural aging and enhance artificial aging. The mechanism controlling the aging is argued to be vacancy diffusion, with solutes trapping vacancies a ...

American Physical Society2014

NutriChip: Nutrition Analysis meets Microfluidics

Martinus Adela Maria Gijs, Sandro Carrara, Paolo Silacci, Julien Michel Ghaye, Gözen Köklü, Hamideh Jafarpoorchekab

This focus article introduces the concept of NutriChip, an integrated microfluidic platform for investigating the potential of the immuno-modulatory function of dairy food. The core component of the NutriChip is a miniaturized artificial human gastrointest ...

Royal Society of Chemistry2013

Immune Engineering Via Differential Antigen Carriers and Co-Stimulatory Molecules

There is an increasing clinical need for vaccines capable of enhancing antigen-specific immune responses and treatments that can induce immunological tolerance toward a single antigen. Here we explore two platforms to enhance either immunization or toleriz ...

EPFL2012

Impaired Humoral Immunity and Tolerance in K14-VEGFR-3-Ig Mice That Lack Dermal Lymphatic Drainage

Melody Swartz

Lymphatic vessels transport interstitial fluid, soluble Ag, and immune cells from peripheral tissues to lymph nodes (LNs), yet the contribution of peripheral lymphatic drainage to adaptive immunity remains poorly understood. We examined immune responses to ...

American Association of Immunologists ; Oxford University Press2012

Therapeutic Immunomodulation of the Lymphoid-like Tumor Environment Using Nanoparticulate Formulations

Cancer is a leading cause of death worldwide. Understanding the underlying mechanisms that lead to tumor escape and evasion is pivotal for the design of new therapeutic applications. This thesis takes an immunobioengineering approach, and navigates through ...

EPFL2012

Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination

Jeffrey Alan Hubbell, Melody Swartz, Marie Ballester

The ability of vaccines to induce memory cytotoxic T-cell responses in the lung is crucial in stemming and treating pulmonary diseases caused by viruses and bacteria. However, most approaches to subunit vaccines produce primarily humoral and only to a less ...

National Academy of Sciences2011

Engineering 3D cell instructive microenvironments by rational assembly of artificial extracellular matrices and cell patterning

Matthias Lütolf, Adrian Ranga

Engineered artificial microenvironments hold enormous potential as models to study developmental, physiological, pathological, and regenerative processes under highly defined conditions. Such platforms aim at bridging the gap between traditional in vitro 2 ...

2011

Cytotoxic profile and peculiar reactivity with biomolecules of a novel “rule-breaker” iodo-platinum(II) complex

Angela Casini

Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to ...

2010

Mathematical Modeling of T-Cell Experimental Data

Irina Baltcheva

T lymphocytes (T cells) are key components of the adaptive immune system. These cells are able to recognize an enormous variety of pathogens thanks to the great specificity of their trans-membrane proteins, the T cell receptors (TCRs). TCR diversity is cre ...

EPFL2010