Friedrich EisenbrandFriedrich Eisenbrand's main research interests lie in the field of discrete optimization, in particular in algorithms and complexity, integer programming, geometry of numbers, and applied optimization. He is best known for his work on efficient algorithms for integer programming in fixed dimension and the theory of cutting planes, which are an important tool to solve large scale industrial optimization problems in practice.
Before joining EPFL in March 2008, Friedrich Eisenbrand was a full professor of mathematics at the University of Paderborn. Friedrich received the Heinz Maier-Leibnitz award of the German Research Foundation (DFG) in 2004 and the Otto Hahn medal of the Max Planck Society in 2001.
Michaël UnserExpertise
Image Processing, Medical Imaging, Biological Imaging, Wavelets, Splines, Multiresolution
Michael Unser is Full Professor with EPFL’s school of Engineering and the academic director of EPFL's Center for Imaging, Lausanne, Switzerland. His primary areas of investigation are signal processing, biomedical imaging and applied functional analysis. He is internationally recognized for his research contributions to sampling theory, wavelets, the use of splines for image processing, stochastic processes,
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Thomas MountfordTeaching & PhD Past EPFL PhD Students Damien Gauthier, Samir Brahim Belhaouari, Driss Baraka, Daniel Rodrigues Valesin, Samuel Schöpfer, Kamran Kalbasi, Jacques Saliba, Hao Xue, Keming Chen Past EPFL PhD Students as codirector Guillaume Charles Woessner Courses Analysis I MATH-101(d) Study the fundamental concepts of analysis, and the differential and integral calculus of real-valued functions of one real variable. Markov chains MATH-332 The course follows the text of Norris
Paolo IennePaolo Ienne has been a Professor at the EPFL since 2000 and heads the Processor Architecture Laboratory (LAP). Prior to that, he worked for the Semiconductors Group of Siemens AG, Munich, Germany (which later became Infineon Technologies AG) where he was at the head of the Embedded Memories unit in the Design Libraries division. His research interests include various aspects of computer and processor architecture, FPGAs and reconfigurable computing, electronic design automation, and computer arithmetic. Ienne was a recipient of Best Paper Awards at the 20th, 24th, and 28th ACM/SIGDA International Symposia on Field-Programmable Gate Arrays (FPGA), in 2012, 2016 and 2020, at the 19th and 30th International Conference on Field-Programmable Logic and Applications (FPL), in 2009 and 2020, at the International Conference on Compilers, Architectures, and Synthesis for Embedded Systems (CASES), in 2007, and at the 40th Design Automation Conference (DAC), in 2003; many other papers have been candidates to Best Paper Awards in prestigious venues. He has served as general, programme, and topic chair of renown international conferences, including organizing in Lausanne the 26th International Conference on Field-Programmable Logic and Applications (FPL) in 2016. He serves on the steering committee of the IEEE Symposium on Computer Arithmetic (ARITH) and of the International Conference on Field-Programmable Logic and Applications (FPL). Ienne has guest edited a number of special issues and special sections on various topics for IEEE and ACM journals. He is regularly member of program committees of international workshops and conferences in the areas of design automation, computer architecture, embedded systems, compilers, FPGAs, and asynchronous design. He has been an associate editor of ACM Transactions on Architecture and Code Optimization (TACO), since 2015, of ACM Computing Surveys (CSUR), since 2014, and of ACM Transactions on Design Automation of Electronic Systems (TODAES) from 2011 to 2016.
Alexandre ButtlerI am a honorary professor at Ecole Polytechnique Fédérale, Lausanne - EPFL. Up to 2019, I was a joint-professor between EPFL (Head of the laboratory of Ecological Systems - ECOS) and the Swiss Federal Research Institute WSL for Forest, Snow and Landscape (Head of the research group Pasture Woodlands and Wetlands) and head of the Site WSL-Lausanne. I was also professor at the laboratory of Chrono-Environnement (UMR CNRS 6249) of the University of Franche-Comté, Besançon (France). I am author or co-author of over 160 papers in international ISI cited peer-reviewed journals.
Emmanuel AbbéTeaching & PhD PhD Students Denys Pushkin, Ortal Yona Senouf, Vladyslav Shashkov Past EPFL PhD Students Elisabetta Cornacchia, Aryo Lotfi Courses Reasoning in artificial intelligence MATH-700 Large language models have raised the potential of artificial intelligence in various applications, including science and mathematics, but their reasoning capabilities remain under investigations. This class focuses on defining, measuring and improving the reasoning capabilities of such AI models.
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Mika Tapani GöösWebsite
https://theory.epfl.ch/mika/
Teaching & PhD PhD Students Valentin Imbach, Ziyi Guan, Artur Riazanov, Anastasiia Sofronova, Weiqiang Yuan Past EPFL PhD Students Maystre Gilbert Théodore Courses Computational complexity CS-524 In computational complexity we study the computational resources needed to solve problems and understand the relation between different types of computation. This course advances the students knowledge of computational complexity, and develop an understanding o Kathryn Hess BellwaldKathryn Hess Bellwald received her PhD from MIT in 1989 and held positions at the universities of Stockholm, Nice, and Toronto before moving to the EPFL.Her research focuses on algebraic topology and its applications, primarily in the life sciences, but also in materials science. She has published extensively on topics in pure algebraic topology including homotopy theory, operad theory, and algebraic K-theory. On the applied side, she has elaborated methods based on topological data analysis for high-throughput screening of nanoporous crystalline materials, classification and synthesis of neuron morphologies, and classification of neuronal network dynamics. She has also developed and applied innovative topological approaches to network theory, leading to a powerful, parameter-free mathematical framework relating the activity of a neural network to its underlying structure, both locally and globally.In 2016 she was elected to Swiss Academy of Engineering Sciences and was named a fellow of the American Mathematical Society and a distinguished speaker of the European Mathematical Society in 2017. In 2021 she gave an invited Public Lecture at the European Congress of Mathematicians. She has won several teaching prizes at EPFL, including the Crédit Suisse teaching prize and the Polysphère d’Or.
Patrick ThiranPatrick Thiran is a full professor in network and systems theory at the School of Computer and Communication Sciences at EPFL. He holds an electrical engineering degree from the Université Catholique de Louvain, Louvain-la-Neuve, Belgium, an M.Sc. degree in electrical engineering from the University of California at Berkeley, USA, and he received the PhD degree from EPFL, in 1996. He became an adjunct professor in 1998, an assistant professor in 2002, an associate professor in 2006 and a full professor in 2011. He was with Sprint Advanced Technology Labs in Burlingame, California, in 2000-01.
His research interests are in communication and social networks, performance analysis and stochastic models. He is currently active in the analysis and design of wireless and PLC networks (scaling laws, medium access control), in network monitoring (network tomography, multi-layer networks), and data-driven network science. He also contributed to network calculus and to the theory of locally coupled neural networks and self-organizing maps.
He served as an associate editor for the IEEE Transactions on Circuits and Systems in 1997-99 and for the IEEE/ACM Transactions on Networking in 2006-10. He is currently on the editorial board of the IEEE Journal on Selected Areas in Communication. He is/was on the program committee of different conferences in networking, including ACM Sigcomm, Sigmetrics, IMC, CoNext and IEEE Infocom. He was TPC chair of AMC IMC 2011 and CoNext 2012. He is a Fellow of the Belgian American Educational Foundation and of the IEEE. He received the 1996 EPFL Doctoral Prize and the 2008 Crédit Suisse Teaching Award.
