David HackerExpertise
Animal cell cultivationTransient transfectionStable cell line generationExpression vector designProtein purification
Teaching & PhD Past EPFL PhD Students as codirector Agata Oberbek, Yashas Rajendra, Xiao Shen, Dominique Terry Monteil Jr, Sowmya Balasubramanian Courses Recombinant protein expression in animal cells for appli-cations in medicine and structural biology BIO-701 Cultivated animal cells are important hosts for the production of recombinant proteins for biochemical and
Sahand Jamal RahiExpertise
- Biophysics- Statistical mechanics- Systems biology- Computational biology- Genetics
Teaching & PhD PhD Students Alisa Gross, Matthieu Schmidt, Marco Labagnara, Lorenzo Scutteri, Haozong Zeng Past EPFL PhD Students Ahmad Sadeghi, Mahsa Barzegarkeshteli, Vojislav Gligorovski, Roxane Oesterle Courses Biophysics : physics of biological systems PHYS-302 Understand and use the results and methods of population genetics, population dynamics, network theory, and reaction network dynami
Wouter Richard KarthausTeaching & PhD PhD Students Jillian Rose Love, Estelle Deby, Ester Simkova, Turan Badalli Courses Cellular and molecular biology II BIO-207 This course is aimed to familiarize students with the 3D organization of a eukaryotic cell, its compartmentalization, how cellular compartments communicate together and how a cell communicates with its environment. The related molecular mechanisms will be discussed. Practical - Karthaus Lab BIO-616 Students will learn 1) how organoids c
Johan AuwerxJohan Auwerx is Professor at the École Polytechnique Fédérale in Lausanne, Switzerland, where he occupies the Nestle Chair in Energy Metabolism. Dr. Auwerx has been using molecular physiology and systems genetics to understand metabolism in health, aging and disease. Much of his work focused on understanding how diet, exercise and hormones control metabolism through changing the expression of genes by altering the activity of transcription factors and their associated cofactors. His work was instrumental for the development of agonists of nuclear receptors - a particular class of transcription factors - into drugs, which now are used to treat high blood lipid levels, fatty liver, and type 2 diabetes. Dr. Auwerx was amongst the first to recognize that transcriptional cofactors, which fine-tune the activity of transcription factors, act as energy sensors/effectors that influence metabolic homeostasis. His research validated these cofactors as novel targets to treat metabolic diseases, and spurred the clinical use of natural compounds, such as resveratrol, as modulators of these cofactor pathways.
Johan Auwerx was elected as a member of EMBO in 2003 and is the recipient of a dozen of international scientific prizes, including the Danone International Nutrition Award, the Oskar Minkowski Prize, and the Morgagni Gold Medal. His work is highly cited by his peers with a h-factor of over 100. He is an editorial board member of several journals, including Cell Metabolism, Molecular Systems Biology, The EMBO Journal, Journal of Cell Biology, Cell, and Science. Dr. Auwerx co-founded a handful of biotech companies, including Carex, PhytoDia, and most recently Mitobridge, and has served on several scientific advisory boards.
Dr. Auwerx received both his MD and PhD in Molecular Endocrinology at the Katholieke Universiteit in Leuven, Belgium. He was a post-doctoral research fellow in the Departments of Medicine and Genetics of the University of Washington in Seattle.
Paul Joseph DysonPaul Dyson joined the Institute of Chemical Sciences and Engineering at the EPFL in 2002 where he heads the Laboratory of Organometallic and Medicinal Chemistry and between 2008 and 2016 chaired the Institute. He has won several prizes including the Werner Prize of the Swiss Chemical Society in 2004, the Award for Outstanding Achievements in Bioorganometallic Chemistry in 2010, the Centennial Luigi Sacconi Medal of the Italian Chemical Society in 2011, the Bioinorganic Chemistry Award of the Royal Society of Chemistry in 2015, the European Sustainable Chemistry Award of the European Chemical Society in 2018 and the Green Chemistry Award from the Royal Society of Chemistry in 2020. He is also a Clarivate Highly Cited Researcher and has an H-index >110 (web of science and google scholar). He was elected a Fellow of the Royal Society of Chemistry in 2010, a Fellow of the European Academy of Science in 2019 and a life-long fellow of the American Association for the Advancement of Science in 2020. Over the years he has held visiting professorships at the University of Bourgogne, University of Pierre et Marie Curie, University of Vienna, University of Rome Tor Vergara, Chimie Paristech and Shangai Jiao Tong University.Since 2016 he has been Member of the Council of the Division of Mathematics, Natural and Engineering Sciences at the Swiss National Science Foundation.Between 2016-2021 he has been Member of the Council of the Division of Mathematics, Natural and Engineering Sciences at the Swiss National Science Foundation. In 2021 he was appointed Dean of the Faculty of Basic Sciences.
Vassily HatzimanikatisDr. Vassily Hatzimanikatis is currently Associate Professor of Chemical Engineering and Bioengineering at Ecole Polytechnique Federale de Lausanne (EPFL), in Lausanne, Switzerland. Vassily received a PhD and an MS in Chemical Engineering from the California Institute of Technology, and his Diploma in Chemical Engineering from the University of Patras, in Greece. After the completion of his doctoral studies, he held a research group leader position at the Swiss Federal Institute of Technology in Zurich (ETHZ), Switzerland. Prior to joining EPFL, Vassily worked for three years in DuPont, Cargill, and Cargill Dow, and he has been assistant professor at Northwestern University, at Illinois, USA.
Vassilys research interests are in the areas of computational systems biology, biotechnology, and complexity. He is associate editor of the journals Biotechnology & Bioengineering, Metabolic Engineering and Integrative Biology, and he serves on the editorial advisory board of the journals Bioprocess and Biosystems Engineering, Journal of Chemical Technology and Biotechnology, and Industrial Biotechnology. He has written over 70 technical publications and he is co-inventor in three patents and patent applications.
Vassily is a fellow of the American Institute for Medical and Biological Engineering (2010), he was a DuPont Young Professor (2001-2004), and he has also received the Jay Bailey Young Investigator Award in Metabolic Engineering (2000), and the ACS Elmar Gaden Award (2011).
Andrea AblasserTeaching & PhD PhD Students Ekaterina Gorbacheva, Iris Arianna Dorschel, Tieliang Gan, Yu Meng Past EPFL PhD Students Simone Margret Haag, Sélène Glück, Marilena Wischnewski, Sophie Rivara, Natasha Samson Courses Immunology - advances and therapeutic implications BIO-479 The students acquire advanced level knowledge regarding the functioning of the (vertebrate) immune system. A strong focus is placed on the molecular mechanisms underlying innate and adaptive immune responses and their impl
Lucia Baldi Unser01/2021 - present Deputy to the Associate VP for Research / Deputy to the Associate VP for Centers & Platforms, EPFL06/2017 - 12/2020 Deputy to the Dean, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne ;01/2015 - 11/2017 Lecturer/Communication and outreach manager at the School of Life Sciences, EPFL04/1998 - 03/2015: Research and Teaching Associate/Lecturer, Laboratory of Cellular Biotechnology, School of Life Sciences; 01/1994 - 07/1997: Visiting Fellow, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, USA;1991 - 1994: Research Fellow, Laboratory of Pediatric Oncology, G. Gaslini Scientific Institute, Genova, Italy;1987 - 1990: Research Fellow, Clinical Immunology and Immunogenetics Dept., Nat. Inst. for Cancer Research, Genova, Italy.
Didier TronoAfter obtaining an M.D. from the University of Geneva and completing a clinical training in pathology, internal medicine and infectious diseases in Geneva and at Massachusetts General Hospital in Boston, Didier Trono embarked in a scientific career at the Whitehead Institute for Biomedical Research of MIT. In 1990, he joined the faculty of the Salk Institute for Biological Studies to launch a center for AIDS research. He moved back to Europe seven years later, before taking the reins of the newly created EPFL School of Life Sciences, which he directed from 2004 to 2012. He is now actively engaged in the efforts of Switzerland to integrate new technologies in the fields of precision medicine and personalized health.
Sandra Eloise KjeldsenPositions
2008- : Laborantine (Laboratoire du Pr D. Trono), Laboratoire de virologie et génétique, EPFL, Suisse.
2004-2008: Laborantine (Laboratoire du Pr A. Trumpp), ISREC, Suisse.
2004: Assistante de recherche (Laboratoire du Pr G. Corradin), Institut de Biochimie, Université de Lausanne, Suisse.
Éducation
1999 - 2004:
Diplôme en Biologie (spécialités : Immunologie, Biochimie et Pharmacologie)
Université de Lausanne, Suisse.
Juin 1999:
Baccalauréat Scientifique, France. Georges WagnièresGeorges Wagnières received his diploma degree (MSc) in physics from the University of Lausanne, Switzerland, in 1986. He obtained his doctorate in science (PhD) in physics (Biomedical optics) from the Swiss Federal Institute of Technology at Lausanne (EPFL) in 1992 and did a postdoctoral work in the Wellman Laboratories of Photomedicine (Harvard Medical School), Boston, USA, from 1993 to 1994. He also obtained a Master degree in Management of Technology delivered by the Ecole des Hautes Etudes Commerciales (HEC) of Lausanne University and the EPFL in 2001. Georges Wagnières manages a research group active in the fields of: - Detection of early superficial cancers by fluorescence imaging. - Characterization of early superficial cancers by high magnification narrow band imaging. - In vivo and in vitro measurement of the vascular and tissular oxygen concentration by time-resolved luminescence spectroscopy and imaging. - Preclinical and clinical study of new photosensitizers for photodynamic therapy (PDT). - Treatment of neurodegenerative conditions (Alzheimer, Parkinson's diseases) by photobiomodulation. - Preclinical and clinical photodynamic therapy of inflammatory bowel diseases and atheroscerotic plaque. - Improvement of the selective vascular extravasation of chemotherapeutic agents by PDT. - Monitoring the light dosimetry during PDT by fluorescence spectroscopy and imaging. - Monitoring laser treatments of the retina by reflectance imaging. - Light dosimetry and tissue optical spectroscopy. - Radiometry. - Development of light delivery systems for biomedical applications. Georges Wagnières is also co-founder and was chairman of one spin-off companies: - Medlight SA, founded in July 1997, which develops, produces and commercializes light distributors for photodynamic therapy. Georges Wagnières has currently authored more than 235 papers (more than 150 in international journals with review board) and is inventor of 18 patents. He supervised 12 PhD students up to now, and currently teaches biomedical optics and photomedicine in master programs and doctoral schools. In addition, he gives the course entitled "Physique Générale I" to biology first year students registered to the Biology School of the Lausanne's University. MAIN PUBLICATIONS Please visit: https://www.epfl.ch/labs/lifmet/wagnieres/publications/ Eugen Brühwilerbirth date: 19.11.1958 nationality: Swiss (native from Dussnang, Canton of Thurgau) Education : - July 1988 : doctoral degree from the Swiss Federal Institute of Technology in Lausanne (EPFL), Switzerland with a thesis entitled Fracture mechanics of dam concrete subjected to quasi-static and seismic loading conditions - December 1983 : civil engineering diploma (university degree) from the Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland Professional Experience : - Since 1st April 1995 : Professor of Structural Engineering at EPFL and Head of the Laboratory of Maintenance, Construction and Safety for Civil Structures (MCS) (often considered being the first chair worldwide devoted exclusively to existing civil structures). - 1991-94 Project Manager and structural engineer with the Swiss Federal Railways (SBB), Division of Bridges and Structures, Zurich: Monitoring and maintenance of bridges and structures, Project manager and checking engineer for the construction of new bridges and rehabilitation of existing bridges. - 1989/90 Research associate at the Department of Civil Engineering, University of Colorado, Boulder, USA : Fracture mechanics of concrete and fracture of concrete dams. - 1986-88 Doctoral student at EPFL-LMC (Building Materials, Prof. Wittmann) : Fracture mechanics of concrete, fracture of concrete dams under seismic loading - 1984/85 Research engineer at EPFL-ICOM (Steel Structures, Prof. Badoux and Prof. Hirt) : Fatigue behaviour and fracture mechanics of riveted bridges
Nicolas ThomäTeaching & PhD PhD Students David Domjan, Pierre Alexander Miranda Herrera, Laurin Tim Kanis, Alessandro Minafra, Pau Reolid Coll Courses Practical - Thomä Lab BIO-624 Expression and purification of recombinant proteins are key methods in our lab studying protein machines on a structural level and ways in which they can be reprogrammed by small molecules. In the course, we will express and purify proteins and biophysically characterise them. Trends in chemical biology and drug discovery
Marie-Pierre ZuffereyDiplôme d'Architecture à l'EPFL en 1988 (prix SIA, section Vaud, du meilleur travail pratique de diplôme).
Collaboration avec plusieurs bureaux d'architecture et, en parallèle, rédaction d'une thèse de doctorat suivie de l'obtention en 1992 du titre de Docteur ès Sciences.
Bureau indépendant de 1996 à 2008; enseignement dans plusieurs écoles (dessin technique, peinture, couleurs).
De 1999 à 2004, première assistante chez les professeurs Arduino Cantàfora (CRE) et Georges Abou Jaoudé (LIV, cours théorique, visualisation et représentation informatique).
De 2005 à 2011, collaboratrice scientifique et chargée de cours auprès du professeur A. Cantàfora (CRE, chaire de représentation et expression) : enseignement pratique du dessin, peinture, et taille de la pierre, et théorique, analyse d'images, techniques de représentation, modes de communication, auprès des étudiants d'architecture de différents niveaux; rédaction de documentation pédagogique (cahiers d'appui des cours).
Charge de cours pour une Unité d'Enseignement ENAC intitulée "Lectures du paysage par le biais de l'image et de l'art" avec Robert Ireland de 2006 à 2008.
Responsable d'une nouvelle Unité d'Enseignement ENAC sur "les murs de soutènement urbains", printemps 2009 et 2010, avec O. Burdet, A. Parriaux, J-L. Moret.
Participation ponctuelle en 2011, 2013 et 2014, pour l'UE-ENAC "Learning from vernacular", du professeur Pierre Frey sur la pierre et les traces de la main dans l'architecture vernaculaire.
Recherche personnelle en cours sur les socles à la Renaissance italienne et française, en lien avec les professeurs Volker Hoffmann (Würzburg) et Roberto Gargiani (EPFL).
Domaines d'intérêt spécifique: l'architecture à la Renaissance; la taille de la pierre et la stéréotomie; le dessin d'observation scientifique, la peinture et la gravure; la philosophie.
