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Concept

Photothermal therapy

Related publications (27)

Porphyrin metalla-assemblies coupled to cellulose nanocrystals for PDT and imaging applications

Georges Wagnières

Photodynamic therapy (PDT) is an interesting and promising approach to tackle a broad spectrum of cancer. With the combination of a photosensitizer, light and oxygen, PDT achieves a unique selectivity by the production of localized reactive oxygen species ...

WORLD SCIENTIFIC PUBL CO PTE LTD2023

Discrete metal nanoparticles with plasmonic chirality

Jijun He

From a geometrical perspective, a chiral object does not have mirror planes or inversion symmetry. It exhibits the same physical properties as its mirror image (enantiomer), except for the chiroptical activity, which is often the opposite. Recent advanceme ...

Royal Society of Chemistry2021

Classification of Metal-Based Drugs according to Their Mechanisms of Action

Paul Joseph Dyson

Metal-based drugs and imaging agents are extensively used in the clinic for the treatment and diagnosis of cancers and a wide range of other diseases. The current clinical arsenal of compounds operate via a limited number of mechanisms, whereas new putativ ...

CELL PRESS2020

Optical Characterization of an Intra-Arterial Light and Drug Delivery System for Photodynamic Therapy of Atherosclerotic Plaque

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Andreas Pitzschke, Ying Xiao

Although the versatility of photodynamic therapy (PDT) is well established, the technical aspects of light delivery systems vary significantly depending on the targeted organ. This article describes the optical properties of a light and drug delivery syste ...

2020

Bladder Cancer Photodynamic Therapeutic Agent with Off-On Magnetic Resonance Imaging Enhancement

Jean-Claude Bünzli

Acting as an extracellular matrix protein receptor, alpha(v)beta(3) integrin becomes an appealing target for photodynamic therapy of bladder cancer. Here, specific alpha(v)beta(3)-integrin-targeting porphyrinato-gadolinium complexes (Gd-PEG-R-n) are demons ...

WILEY2019

Functionalization of second harmonic generation nanoparticles for theranostic applications

Jérémy Vuilleumier

Nowadays, cancer is one of the leading causes of death in developed countries. The actual medical tools to detect cancer at early stage suffer to their low sensitivity. The design of multimodal nanodevices for in vivo imaging offers the perspective of canc ...

EPFL2019

Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity

Paul Joseph Dyson, Zhaofu Fei

Multi-layered single-walled carbon nanotubes, t ermed SWNT@BSA@Au-S-PEG -FA@DOX, which int egrate photothermal therapy with small molecule drug delivery, were prepared using a facile layer-by-layer assembly process. Oxidized and eut single-walled carbon na ...

2018

Gold Raspberry-Like Colloidosomes Prepared at the Water-Nitromethane Interface

Hubert Girault, Pekka Eero Peljo, Evgeny Smirnov

Here, we propose a simple shake-flask method to produce micron-size colloidosomes from a liquid-liquid interface functionalized with a gold nanoparticle film. A step-by-step extraction process of an organic phase partially miscible with water led to the fo ...

2018

Stepwise growth of gold coated cancer targeting carbon nanotubes for the precise delivery of doxorubicin combined with photothermal therapy

Paul Joseph Dyson, Zhaofu Fei

Combining doxorubicin with thermal therapy in the clinic has led to startling results in the treatment of problematic cancers. Here, we describe a multimo dal multi-walled carbon nanotube material that combines tumor targeting, doxorubicin delivery, and ph ...

Royal Society of Chemistry2017

Upconversion fluorescence imaging of HeLa cells using ROS generating SiO2-coated lanthanide-doped NaYF4 nanoconstructs

Andrzej Sienkiewicz

Inorganic nanomaterials able to generate reactive oxygen species (ROS) are promising components for modern medical applications. Activated by near-infrared light, up-converting beta-NaYF4 doped with Er3+ - Yb3+ and Tm3+- Yb3+ pair ions nanoparticles (UCNPs ...

2017

In vivo measurement of the tissue oxygenation by time-resolved luminescence spectroscopy of protoporphyrin IX: Strategies to minimize artefacts associated with photoproducts

Georges Wagnières, Veronika Huntosova, Emmanuel Louis Arthur Gerelli

The determination of the oxygen partial pressure (pO(2)) in real time in living biological tissues is of high interest for numerous therapeutics, including photodynamic therapy (PDT) and radiotherapy. The minimally invasive and real-time measurement of the ...

Spie-Int Soc Optical Engineering2017

Review of the role played by the photosensitizer's photobleaching during photodynamic therapy

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Photodynamic therapy (PDT) is based on the combined administration of photosensitizing drugs and light to treat a variety of malignant, pre-malignant and also non-malignant diseases. The reactive species resulting from the excitation of the photosensitizer ...

Natl Inst Optoelectronics2016

Fluence plays a critical role on the subsequent distribution of chemotherapy and tumor growth delay in murine mesothelioma xenografts pre-treated by photodynamic therapy

Georges Wagnières

Background: The pre-conditioning of tumor vessels by low-dose photodynamic therapy (L-PDT) was shown to enhance the distribution of chemotherapy in different tumor types. However, how light dose affects drug distribution and tumor response is unknown. Here ...

Wiley-Blackwell2015

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Andrea Brett Gasser, Débora Bonvin

Tumor vasculature is known to be poorly organized leading to increased leakage of molecules to the extravascular space. This process can potentially increase interstitial fluid pressure impairing intra-tumoral blood flow and oxygen supply, and can affect d ...

Nature Publishing Group2015

Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis

Melody Swartz, Patrycja Nowak-Sliwinska

Lymphatic vessels transport fluid, antigens, and immune cells to the lymph nodes to orchestrate adaptive immunity and maintain peripheral tolerance. Lymphangiogenesis has been associated with inflammation, cancer metastasis, autoimmunity, tolerance and tra ...

Springer2014

Low-dose angiostatic tyrosine kinase inhibitors improve photodynamic therapy for cancer: lack of vascular normalization

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Andrea Brett Gasser, Débora Bonvin

Photodynamic therapy (PDT) is an effective clinical treatment for a number of different cancers. PDT can induce hypoxia and inflammation, pro-angiogenic side effects, which may counteract its angio-occlusive mechanism. The combination of PDT with anti-angi ...

2014

Photodynamic therapy for polypoidal choroidal vasculopathy

Hubert van den Bergh, Patrycja Nowak-Sliwinska

The first effective therapy for exudative macular degeneration (AMD) was Photodynamic Therapy (PDT). Diagnosis of the disease was to a large extent by fluorescein angiography (FA). Distinguishing between the leaky choroidal neovessels (CNV) associated with ...

Pergamon-Elsevier Science Ltd2013

Gold Nanoparticles Grown on Ionic Liquid-Functionalized Single-Walled Carbon Nanotubes: New Materials for Photothermal Therapy

Paul Joseph Dyson, Zhaofu Fei

Gold nanoparticles were grown on single-walled carbon nanotubes (SWNTs) coated with a thiol-functionalized ionic liquid resulting in the formation of core-shell structures referred to as SWNT-IL-Au nanohybrid materials. The nanohybrid materials were charac ...

Wiley-V C H Verlag Gmbh2012

Like a Bolt from the Blue: Phthalocyanines in Biomedical Optics

Hubert van den Bergh

The purpose of this review is to compile preclinical and clinical results on phthalocyanines (Pcs) as photosensitizers (PS) for Photodynamic Therapy (PDT) and contrast agents for fluorescence imaging. Indeed, Pcs are excellent candidates in these fields du ...

Molecular Diversity Preservation International2012

Real-time, in vivo measurement of tissular pO(2) through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska, Anna Maria Novello, Cédric Xavier Paulou

Tissular oxygen concentration plays a key role during photodynamic therapy (PDT). Therefore, monitoring its local oxygen partial pressure (pO(2)) may help predict and/or control the outcome of a PDT treatment. The first real-time, in vivo measurements of t ...

SPIE Society of Photo-optical Instrumentation Engineers2012