Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Rüdiger UrbankeRüdiger L. Urbanke obtained his Dipl. Ing. degree from the Vienna University of Technology, Austria in 1990 and the M.Sc. and PhD degrees in Electrical Engineering from Washington University in St. Louis, MO, in 1992 and 1995, respectively. He held a position at the Mathematics of Communications Department at Bell Labs from 1995 till 1999 before becoming a faculty member at the School of Computer & Communication Sciences (I&C) of EPFL. He is a member of the Information Processing Group. He is principally interested in the analysis and design of iterative coding schemes, which allow reliable transmission close to theoretical limits at low complexities. Such schemes are part of most modern communications standards, including wireless transmission, optical communication and hard disk storage. More broadly, his research focuses on the analysis of graphical models and the application of methods from statistical physics to problems in communications. From 2000-2004 he was an Associate Editor of the IEEE Transactions on Information Theory and he is currently on the board of the series "Foundations and Trends in Communications and Information Theory." In 2017 he was President of the Information Theory Society. From 2009 till 2012 he was the head of the I&C doctoral school, in 2013 he served as Dean a. i. of I&C, and since 2016 he is the Associated Dean for teaching of I&C. He is a co-author of the book "Modern Coding Theory" published by Cambridge University Press. Awards: 2021 IEEE Information Theory Society Paper Award 2016 STOC Best Paper Award 2014 La Polysphere Teaching Award 2014 IEEE Hamming Medal 2013 IEEE Information Theory Society Paper Award 2011 MASCO Best Paper Award 2011 IEEE Koji Kobayashi Award 2009 La Polysphere Teaching Award 2002 IEEE Information Theory Society Paper Award Fulbright Scholarship My students have won the following awards: M. Mondelli, 2021 IEEE Information Theory Paper Award M. Mondelli, EPFL Doctorate Award 2018 M. Mondelli, Patrick Denantes Award, 2017 M. Mondelli, IEEE IT Society Student Paper Award at ISIT, 2015 M. Mondelli, Dan David Prize Scholarship, 2015 H. Hassani, Inaugural Thomas Cover Dissertation Award, 2014 S. Kudekar, 2013 & 2021 IEEE Information Theory Paper Award A. Karbasi, Patrick Denantes Award, 2013 V. Venkatesan, Best Paper Award at MASCOTS, 2011 A. Karbasi, Best Student Paper Award at ICASSP, 2011 (with R. Parhizkar) A. Karbasi, Best Student Paper Award at ACM SIGMETRICS, 2010 (with S. Oh) S. Korada, ABB Dissertation Award, 2010 S. Korada, IEEE IT Society Student Paper Award at ISIT, 2009 (with E. Sasoglu) S. Korada, IEEE IT Society Student Paper Award at ISIT, 2008
Sabine SüsstrunkProf. Dr. Sabine Süsstrunk leads the Image and Visual Representation Lab in the School of Computer and Communication Sciences (IC) at EPFL since 1999. From 2015-2020, she was also the first Director of the Digital Humanities Institute (DHI), College of Humanities (CdH). Her main research areas are in computational photography, computational imaging, color image processing and computer vision, machine learning, and computational image quality and aesthetics. Sabine has authored and co-authored over 200 publications, of which 7 have received best paper/demo awards, and holds over 10 patents. Sabine served as chair and/or committee member in many international conferences on image processing, computer vision, and image systems engineering. She is President of the Swiss Science Council SSC, Founding Member and Member of the Board (President 2014-2018) of the EPFL-WISH (Women in Science and Humanities) Foundation, Member of the Board of the SRG SSR (Swiss Radio and Television Corporation), and Member of the Board of Largo Films. She received the IS&T/SPIE 2013 Electronic Imaging Scientist of the Year Award for her contributions to color imaging, computational photography, and image quality, and the 2018 IS&T Raymond C. Bowman and the 2020 EPFL AGEPoly IC Polysphere Awards for excellence in teaching. Sabine is a Fellow of IEEE and IS&T.
Anastasios VassilopoulosPERSONAL INFORMATION Name : Anastasios P. Vassilopoulos email : anastasios.vassilopoulos@epfl.ch Tel: 41 21 6936393 Fax: 41 21 6936240 SUMMARY OF QUALIFICATIONS 1995: Dipl. Mechanical Engineer, University of Patras, Greece 2001: Dr Mechanical Engineer, Doctoral thesis in fatigue of composite materials from the Dept. Mechanical Engineering and Aeronautics, University of Patras, Greece CURRENT POSITION Senior Scientist (MER), Composite Construction Laboaratory (CCLab), EPFL PREVIOUS POSITIONS 2006-2012 Research and Teaching Associate, Composite Construction Laboaratory (CCLab), EPFL 2002-2006 Assisstant Professor, Technological Educational Institute (TEI) of Patras, Greece 2001-2003 Post-doctoral Research associate, (Part-time) Dept. Mechanical Engineering and Aeronautics of the University of Patras, Greece. EDUCATION 1990 - 1995 Graduate student, Dept. Mechanical Engineering and Aeronautics, University of Patras, Greece October 1994-January 1995 Dept. Mechanical Engineering, University of Bristol, U.K. (In the frame of Erasmus project for the final year thesis, under the supervision of Prof. R. D. Adams) 1995 - 2000 Research assistant, Dept. Mechanical Engineering and Aeronautics, University of Patras. LANGUAGES English, Greek, French COMMUNITY ACTIVITIES (Member of) Council of the European Society of Composite Materials (ESCM) Council of the European Society of Experimental Mechanics (EuraSEM) The European Structural Integrity Society (ESIS) The European Energy Research Alliance (EERA, JP WIND) The Technical Chamber of Greece (TCG) The Hellenic Association of Mechanical & Electrical Engineers SCIENTIFIC-RESEARCH INTERESTS Experimental methods for the study of the behavior of composite materials under static and fatigue loading Development of analytical methods for the study of the behavior of FRP composite materials under variable amplitude complex stress states Development of fatigue life prediction methodologies for composite materials and structures Design of constructions with composite materials Emmanuel AbbéTeaching & PhD PhD Students Denys Pushkin, Ortal Yona Senouf, Vladyslav Shashkov Past EPFL PhD Students Elisabetta Cornacchia, Aryo Lotfi Courses Reasoning in artificial intelligence MATH-700 Large language models have raised the potential of artificial intelligence in various applications, including science and mathematics, but their reasoning capabilities remain under investigations. This class focuses on defining, measuring and improving the reasoning capabilities of such AI models.
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Olivier SchneiderAfter his thesis defense in particle physics in 1989 at University of Lausanne, Olivier Schneider joins LBL, the Lawrence Berkeley Laboratory (California), to work on the CDF experiment at the Tevatron in Fermilab (Illinois), first as a research fellow supported by the Swiss National Science Foundation, and later as a post-doc at LBL. He participates in the construction and commissioning of the first silicon vertex detector to operate successfully at a hadron collider; this detector enabled the discovery of the sixth quark, named "top". Since 1994, he comes back to Europe and participates in the ALEPH experiment at CERN's Large Electron-Positron Collider, as CERN fellow and then as CERN scientific staff. He specializes in heavy flavour physics. In 1998, he becomes associate professor at University of Lausanne, then extraordinary professor at the Swiss Institute of Technology Lausanne (EPFL) in 2003, and finally full professor at EPFL in 2010. Having worked since 1997 on the preparation of the LHCb experiment at CERN's Large Hadron Collider, which started operation in 2009, he is now analyzing the first data. He also contributes since 2001 to the exploitation of the data recorded at the Belle experiment (KEK laboratory, Tsukuba, Japan). These two experiments study mainly the decays of hadrons containing a b quark, as well CP violation, i.e. the non-invariance under the symmetry between matter and antimatter.
Sylvain CalinonExpertise
robot learning, human-robot collaboration, optimal control, model-based optimization
I am a Senior Research Scientist at the Idiap Research Institute and a Lecturer at EPFL, with research interests covering robot learning, optimal control, geometrical approaches, and human-robot collaboration. My work focuses on human-centered robotics applications in which the robots can acquire new skills from only few demonstrations and interactions. It requires the development of models that can exploit the st
Michaela HirschmannTeaching & PhD PhD Students Patrick Hirling, Jonathan Petersson, Lucie Scharré Courses Astrophysics III : galaxy formation and evolution PHYS-465 Galaxy formation & evolution is about studying how galaxies in our Universe come into existence, how they evolve and what shapes their properties. This course describes the observational facts of galaxies and the various processes of galaxy evolution as seen from theoretical/numerical models. General physics : thermodynamics (English) P
Patrick ThiranPatrick Thiran is a full professor in network and systems theory at the School of Computer and Communication Sciences at EPFL. He holds an electrical engineering degree from the Université Catholique de Louvain, Louvain-la-Neuve, Belgium, an M.Sc. degree in electrical engineering from the University of California at Berkeley, USA, and he received the PhD degree from EPFL, in 1996. He became an adjunct professor in 1998, an assistant professor in 2002, an associate professor in 2006 and a full professor in 2011. He was with Sprint Advanced Technology Labs in Burlingame, California, in 2000-01.
His research interests are in communication and social networks, performance analysis and stochastic models. He is currently active in the analysis and design of wireless and PLC networks (scaling laws, medium access control), in network monitoring (network tomography, multi-layer networks), and data-driven network science. He also contributed to network calculus and to the theory of locally coupled neural networks and self-organizing maps.
He served as an associate editor for the IEEE Transactions on Circuits and Systems in 1997-99 and for the IEEE/ACM Transactions on Networking in 2006-10. He is currently on the editorial board of the IEEE Journal on Selected Areas in Communication. He is/was on the program committee of different conferences in networking, including ACM Sigcomm, Sigmetrics, IMC, CoNext and IEEE Infocom. He was TPC chair of AMC IMC 2011 and CoNext 2012. He is a Fellow of the Belgian American Educational Foundation and of the IEEE. He received the 1996 EPFL Doctoral Prize and the 2008 Crédit Suisse Teaching Award.
Dominique BonvinDominique Bonvin is Professor and Director of the Automatic Control Laboratory of EPFL. He received his Diploma in Chemical Engineering from ETH Zürich, and his Ph.D. degree from the University of California, Santa Barbara. He worked in the field of process control for the Sandoz Corporation in Basel and with the Systems Engineering Group of ETH Zürich. He joined the EPFL in 1989, where his current research interests include modeling, control and optimization of dynamic systems. He served as Director of the Automatic Control Laboratory for the periods 1993-97, 2003-2007 and again since 2012, Head of the Mechanical Engineering Department in 1995-97 and Dean of Bachelor and Master Studies at EPFL for the period 2004-2011.
