Concept

Nerve guidance conduit

Related publications (29)

Required growth facilitators propel axon regeneration across complete spinal cord injury

Grégoire Courtine, Mark Andrew Anderson, Nicholas David James, Cheng Wang, Sabry Leonardo Barlatey, Michael V. Sofroniew

Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury1,2,3, but efficient reversal of this regrowth failure ...

2018

In vitro evaluation of gel-encapsulated adipose derived stem cells: Biochemical cues for in vivo peripheral nerve repair

Stéphanie Lacour

Adipose‐derived stem cells (ASC) are becoming one of the most exploited cells in peripheral nerve repair. They are fast‐growing and able to protect neurons from apoptosis; they can reduce postinjury latency and the risk of muscle atrophy. This study evalua ...

Wiley-Blackwell2017

Fascicular nerve stimulation and recording using a novel double-aisle regenerative electrode

Silvestro Micera

Objective. As artificial prostheses become more refined, they are most often used as a therapeutic option for hand amputation. By contrast to extra- or intraneural interfaces, regenerative nerve electrodes are designed to enable electrical interfaces with ...

Iop Publishing Ltd2017

Influencing axon regeneration after spinal cord injury

Mark Andrew Anderson

Spinal cord injury (SCI) results in a severing of axonal connections that leads to permanent sensorimotor deficits. In cases of incomplete injury, rehabilitation paradigms have been reported to be successful in improving behavioral outcome in humans with S ...

EPFL2017

Long-term usability and bio-integration of polyimide-based intraneural stimulating electrodes

Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Stanisa Raspopovic, Alessandra Piersigilli, Quentin Barraud, Nawal Noëlle Kinany, Jacopo Rigosa, Sophie Marie Marthe Wurth, Jérôme Gandar, Natalia Pavlova

Stimulation of peripheral nerves has transiently restored lost sensation and has the potential to alleviate motor deficits. However, incomplete characterization of the long-term usability and bio-integration of intra-neural implants has restricted their us ...

Elsevier Sci Ltd2017

Preferential Enhancement of Sensory and Motor Axon Regeneration by Combining Extracellular Matrix Components with Neurotrophic Factors

Silvestro Micera

After peripheral nerve injury, motor and sensory axons are able to regenerate but inaccuracy of target reinnervation leads to poor functional recovery. Extracellular matrix (ECM) components and neurotrophic factors (NTFs) exert their effect on different ne ...

2017

Focal release of neurotrophic factors by biodegradable microspheres enhance motor and sensory axonal regeneration in vitro and in vivo

Silvestro Micera

Neurotrophic factors (NTFs) promote nerve regeneration and neuronal survival after peripheral nerve injury. However, drawbacks related with administration and bioactivity during long periods limit their therapeutic application. In this study, PLGA microsph ...

Elsevier Science Bv2016

Interactions of Peripheral Nerve Cells with Soft Micropillar Interfaces

Cédric Xavier Paulou

Regenerative peripheral nerve interfaces are particularly invasive implant devices. They rely on the growth of axons from transected nerve stumps through electrode-bearing structures in order to establish highly efficient communication channels with the ne ...

EPFL2015

Chronic multichannel neural recordings from soft regenerative microchannel electrodes during gait

Silvestro Micera, Stéphanie Lacour, Marco Capogrosso, Sophie Marie Marthe Wurth, Katherine Marie Musick, Jacopo Rigosa

Reliably interfacing a nerve with an electrode array is one of the approaches to restore motor and sensory functions after an injury to the peripheral nerve. Accomplishing this with current technologies is challenging as the electrode-neuron interface ofte ...

Nature Publishing Group2015