Mathilde Stéphanie WilleminExpertise
Dynamic and enthusiastic biochemist with a phD in microbiology. Happy to help you realize your project from experimental design to data analysis.
Hubert GiraultEducation: 1979 - Engineering diploma from Grenoble Institute of Technology. FRANCE. 1982 - PhD- Department of Chemistry, University of Southampton. Thesis entitled : Interfacial studies using drop image processing techniques. Positions : 1982 - 1984 SERC Research Fellow. University of Southampton. 1984 - 1985 CNRS Research Fellow. University of Southampton. 1985 - 1992 Lecturer in Physical Chemistry, University of Edinburgh. 1992 - Professor of Physical Chemistry, Ecole Polytechnique Fédérale de Lausanne. 2011 - 2014 Dean of Bachelor and Master studies Hubert Girault is the author of 2 textbooks, the co-author of about 600 scientific publications with more than 20'000 citations and the co-inventor of more than 15 patents. During his academic career, he has supervised 70 PhD students. 30 alumni of his laboratory are now Professors. Honours: Faraday medal 2006, Royal Society of Chemistry, Fellow of the International Society of Electrochemistry 2007, Reilley Award 2015. Fellow of the Electrochemical Society (USA), Shikata International medal, Polarography Society of Japan. Associate editor of Chemical Science
Georges WagnièresGeorges Wagnières received his diploma degree (MSc) in physics from the University of Lausanne, Switzerland, in 1986. He obtained his doctorate in science (PhD) in physics (Biomedical optics) from the Swiss Federal Institute of Technology at Lausanne (EPFL) in 1992 and did a postdoctoral work in the Wellman Laboratories of Photomedicine (Harvard Medical School), Boston, USA, from 1993 to 1994. He also obtained a Master degree in Management of Technology delivered by the Ecole des Hautes Etudes Commerciales (HEC) of Lausanne University and the EPFL in 2001. Georges Wagnières manages a research group active in the fields of: - Detection of early superficial cancers by fluorescence imaging. - Characterization of early superficial cancers by high magnification narrow band imaging. - In vivo and in vitro measurement of the vascular and tissular oxygen concentration by time-resolved luminescence spectroscopy and imaging. - Preclinical and clinical study of new photosensitizers for photodynamic therapy (PDT). - Treatment of neurodegenerative conditions (Alzheimer, Parkinson's diseases) by photobiomodulation. - Preclinical and clinical photodynamic therapy of inflammatory bowel diseases and atheroscerotic plaque. - Improvement of the selective vascular extravasation of chemotherapeutic agents by PDT. - Monitoring the light dosimetry during PDT by fluorescence spectroscopy and imaging. - Monitoring laser treatments of the retina by reflectance imaging. - Light dosimetry and tissue optical spectroscopy. - Radiometry. - Development of light delivery systems for biomedical applications. Georges Wagnières is also co-founder and was chairman of one spin-off companies: - Medlight SA, founded in July 1997, which develops, produces and commercializes light distributors for photodynamic therapy. Georges Wagnières has currently authored more than 235 papers (more than 150 in international journals with review board) and is inventor of 18 patents. He supervised 12 PhD students up to now, and currently teaches biomedical optics and photomedicine in master programs and doctoral schools. In addition, he gives the course entitled "Physique Générale I" to biology first year students registered to the Biology School of the Lausanne's University. MAIN PUBLICATIONS Please visit: https://www.epfl.ch/labs/lifmet/wagnieres/publications/ Jan Sickmann HesthavenProf. Hesthaven received an M.Sc. in computational physics from the Technical University of Denmark (DTU) in August 1991. During the studies, the last 6 months of 1989 was spend at JET, the european fusion laboratory in Culham, UK. Following graduation, he was awarded a 3 year fellowship to begin work towards a Ph.D. at Riso National Laboratory in the Department of Optics and Fluid Dynamics. During the 3 years of study, the academic year of 1993-1994 was spend in the Division of Applied Mathematics at Brown University and three 3 months during the summer of 1994 in Department of Mathematics and Statistics at University of New Mexico. In August 1995, he recieved a Ph.D. in Numerical Analysis from the Institute of Mathematical Modelling (DTU). Following graduation in August 1995, he was awarded an NSF Postdoctoral Fellowship in Advanced Scientific Computing and was approinted Visiting Assistant Professor in the Division of Applied Mathematics at Brown University. In December of 1996, he was appointed consultant to the Institute of Computer Applications in Science and Engineering(ICASE) at NASA Langley Research Center (NASA LaRC). As of July 1999, he was appointed Assistant Professor of Applied Mathematics, in September 2000 he was awarded an Alfred P. Sloan Fellowship, as of July 2001 he was awarded a Manning Assistant Professorship, and in March 2002, he was awarded an NSF Career Award. In January 2003, he was promoted to Associate Professor of Applied Mathematics with tenure and in May 2004 he was awarded Philip J. Bray Award for Excellence in Teaching in the Sciences (the highest award given for teaching excellence in all sciences at Brown University). He was promoted to Professor of Applied Mathematics as of July 2005. From October 2006 to June 2013, he was the Founding Director of the Center for Computation and Visualization (CCV) at Brown University. As of October 2007, he holds the (honorary) title of Professor (Adjunct) at the Technical University of Denmark. In November 2009, he successfully defended his dr.techn thesis at the Technical University of Denmark and was rewarded the degree of Doctor Technices -- the highest academic distinction awarded based on ... substantial and lasting contributions that has helped to move the research area forward and penetrated into applications. As grant Co-PI he served from Aug 2010 to June 2013 as Deputy Director of the Institute of Computational and Experimental Research in Mathematics (ICERM), the newest NSF Mathematical Sciences Research Institute. After having spend his entire academic career at Brown University, Prof Hesthaven decided to pursue new challenges and joined the Mathematics Institute of Computational Science and Engineering (MATHICSE) at Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland in July 2013. In March 2014 he was elected SIAM Fellow for contributions to high-order methods for partial differential equations.
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Luciano Andres AbriataExpertise
Protein NMRNMR of paramagnetic systemsMetalloproteinsBiomolecular SpectroscopyStructural BiologyStructural BioinformaticsMolecular Modeling
ResearchPapers Link to Google Scholar
Teaching & PhD Courses Basic and advanced NMR - Level 1 A (EPFL) CH-601(x) Basic theoretical and experimental aspects of NMR will be taught. Students will be familarized with modern NMR spectrometers. Basic and advanced NMR - Level 2 (EPFL) CH-703 The goal is to give a sound theoretical an
Quentin BarraudExpertise
Translational neuroscience · Neuromodulation · Spinal cord injury & Parkinson’s disease · Multi-omics (single-cell, spatial transcriptomics, 3D cleared-tissue imaging) · Preclinical platform management
Mission
To develop, coordinate, and supervise the preclinical activities of .NeuroRestore at EPFL, integrating innovative neuromodulation, gene therapy, and multi-omic strategies. To ensure regulatory compliance of all animal work, support scientific teams in experimental design, and build bridges b
Jocelyne BlochTeaching & PhD PhD Students Camille Marie Mélodie Frayssinhes Past EPFL PhD Students as codirector Sabry Barlatey, Aasta Parin Gandhi
Ute KochExpertise
SCIENTIFIC EXPERTISESCurrent Molecular Biology and Cloning, Developmental Biology, Cellular and Molecular Immunology, Lymphocyte Maturation and Lineage Commitment, Thymic Selection, Hematopoietic Stem Cell Biology, Bone Marrow Transplantation, Graft-versus-Host Disease, Skin Transplantation, T Lymphocyte Subset Induction (Th1 - Th2, Cytokine Regulation), Extensive Knowledge in Flow CytometryIT SKILLSMicrosoft-Office: Word, Excel, PowerPoint.File Maker Pro: Database design and management.Flow cytom
Rizlan Bernier-LatmaniHIGHER EDUCATION
Summer course: Advances in Genome Technology and Bioinformatics Course at the Marine Biology Laboratory in Woods Hole, MA. October 2005.
Ph.D. 2001 Civil and Environmental Engineering, Stanford University, CA
(Advisor, Jim Leckie, Biodegradation of uranyl (UO22 )-complexed citrate and implications for uranyl mobility in the subsurface)
M.S. 1995 Civil and Environmental Engineering, Stanford University, CA
B.S. 1993 Natural Resources with Honors, Cornell University, Ithaca, NY
PROFESSIONAL EMPLOYMENT
2013-present Associate professor with tenure, School of Architecture, Civil and Environmental Engineering, Swiss Federal Institute of Technology, Lausanne
2005-2013 Assistant professor tenure track, School of Architecture, Civil and Environmental Engineering, Swiss Federal Institute of Technology, Lausanne
2001-2005 Post-Graduate Researcher, Scripps Institution of Oceanography, La Jolla, CA (PI: Brad Tebo)
1995-2001 Graduate Research Assistant, Stanford University (Advisor: Jim Leckie)
RESEARCH INTERESTS
Gemicrobiology, metal-bacteria interactions, biological reduction and oxidation of metals, biological nanoparticle formation; Characterization of microbial communities in terrestrial environments; Using genomic, microscopic and spectroscopic tools to understand metal transformations by microorganisms.
ACADEMIC HONORS
Rotary Foundation University Professor grant, 2004.
Swiss National Science Foundation Post-doctoral Fellowship, 2001.
Leon B. Reynolds Memorial Scholarship in the School of Engineering at Stanford University, 1995-96.
Graduated with Honors from Cornell University, 1993.
BIBLIOMETRY
http://www.researcherid.com/rid/E-4398-2011
ResearcherID: E-4398-2011 Stephan MorgenthalerACADEMIC POSITIONS
Professor of Applied Statistics, EPFL, 1988-present
Associate Professor of Statistics, Yale University, 1987-1988
Assistant Professor of Statistics, Yale University, 1983-1987
Instructor of Mathematics, Massachusetts Institute of Technology, 1983-1984
Nicolas GrandjeanNicolas Grandjean received a PhD degree in physics from the University ofNice Sophia Antipolis in 1994 and shortly thereafter joined the French National Center for Scientific Research (CNRS) as a permanent staff member. In 2004, he was appointed tenure-track assistant professor at the École polytechnique fédérale de Lausanne (EPFL) where he created the Laboratory for advanced semiconductors for photonics and electronics. He was promoted to full professor in 2009. He was the director of the Institute of Condensed Matter Physics from 2012 to 2016 and then moved to the University of California at Santa Barbara where he spent 6 months as a visiting professor. Since 2018, he is the head of the School of Physics at the EPFL. He was awarded the Sandoz Family Foundation Grant for Academic Promotion, received the “Nakamura Lecturer” Award in 2010, the "Quantum Devices Award” at the 2017 Compound Semiconductor Week, and “2016 best teacher” award from the EPFL Physics School. His research interests are focused on the physics of nanostructures and III-V nitride semiconductor quantum photonics.
Esther AmstadEsther Amstad studied material science at ETH in Zurich. She also carried out her PhD thesis at the same University under the supervision of Prof. Marcus Textor; for her thesis, she worked on the surface modification and steric stabilization of oxide nanoparticles. As a postdoctoral fellow, she joined the experimental condensed soft matter group of David A. Weitz at Harvard University where she used droplet based microfluidics to assemble different types of functional micro- and nanomaterials. In addition, she developped new microfluidic devices that enable the production of very small, airborne drops as well as devices that produce highly monodisperse emulsion drops at a very high throughput. In June 2014, Esther joined the material science department (IMX) of EPFL where she is leading the Soft Materials Laboratory (SMAL).
