Esther AmstadEsther Amstad studied material science at ETH in Zurich. She also carried out her PhD thesis at the same University under the supervision of Prof. Marcus Textor; for her thesis, she worked on the surface modification and steric stabilization of oxide nanoparticles. As a postdoctoral fellow, she joined the experimental condensed soft matter group of David A. Weitz at Harvard University where she used droplet based microfluidics to assemble different types of functional micro- and nanomaterials. In addition, she developped new microfluidic devices that enable the production of very small, airborne drops as well as devices that produce highly monodisperse emulsion drops at a very high throughput. In June 2014, Esther joined the material science department (IMX) of EPFL where she is leading the Soft Materials Laboratory (SMAL).
Marie Estelle Solange ViolayExpertise
-Rock mechanics-Rock physics-Fault and earthquake mechanics-Hydro-mechanical couplings
Teaching & PhD PhD Students Cindy Mikaelian, Francesco Lazari, Franco Matías Robbiano Muñoz, Karin Andrea Hofer Apostolidis, Andrea Mazzeo Past EPFL PhD Students Felipe Orellana, Mateo Acosta, Chiara Cornelio, Corentin Noël, Federica Paglialunga, Antoine Guggisberg Courses Designing Testing Machines for Geomechanics ME-700 Develop your own machines to meet your scientific needs. Learn how to bu
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Jacques RappazOriginaire de Neyruz-sur-Moudon (VD), Jacques Rappaz est né le 22 mars 1947. Après ses études primaires et secondaires à Lausanne, il étudie la physique, de 1964 à 1970, à l'Ecole Polytechnique de l'Université de Lausanne (EPUL et EPFL dès 1969) où il obtient son diplôme en janvier 1971. Il entreprend ensuite un travail de recherche en analyse numérique à l'EPFL. En avril 1976, il soutient une thèse consacrée à l'approximation spectrale d'opérateurs provenant de la physique des plasmas.De 1977 à 1980, il es
Stefano CodaTeaching & PhD PhD Students Vincent Masson, Luigi Persico, Ewout Koen L. Devlaminck, Martino Bonisolli, Alessandro Balestri, Mackenzie Peter-Fulford Van Rossem, James Winston Irawati Tumbokon, Salomon Guinchard, Inès Vergara, Michele Bottino Past EPFL PhD Students Alessandro Marinoni, Silvano Gnesin, Cornelis Adrianus de Meijere, Josef Kamleitner, Zhouji Huang, Himank Anand, Pedro Andres Molina Cabrera, Dahye Choi, Federico Pesamosca, Aylwin Iantchenko, Jean Arthur Cazabonne
Justin Richard BallDr. Justin Ball is a staff scientist studying theoretical plasma physics and nuclear fusion energy. His research primarily focuses on the effect of plasma shaping on turbulence in tokamaks. He is the principle investigator of the EUROfusion Theory, Simulation, Verification, and Validation project on negative triangularity. Additionally, he is an avid fusion science communicator via magazine articles, lectures, and podcasts. In 2019, he and Jason Parisi published a popular science book titled The Future of F
Azin AminiEducation:
MSc.: Structural Engineering, University of Tehran, Iran, 2002
Master Thesis: "Three dimensional analysis of crack propagation in Latiyan butress dam using smeard crack model"
BSc.: Civil Engineering, University of Tehran, Iran, 2000
Hervé LissekExpertise
Acoustics and audio engineering, Electroacoustics.Room acoustics.Active noise control.Acoustic metamaterials.Assisted reverberation.Psychoacoustics.Sound spatialization
Expertise
Acoustics and audio engineering, Electroacoustics.Room acoustics.Active noise control.Acoustic metamaterials.Assisted reverberation.Psychoacoustics.Sound spatialization
Mission
Head of the Acoustic Group at the Laboratory of Wave Engineering LWE. Research topics :Active Electroacoustic Resonators: turning conventional lou
